I think you have to take this with a grain of salt, but yes, according to this dubious Russian source. The article bases part of its argument on Giphys of Terminator 2 and 2012.

The president of the Academy of Geopolitical Problems believes that an “asymmetrical response” would work much better for Russia, as it is able to produce nuclear weapons with a yield of more than 100 megatons.

If “areas with critically dangerous geophysical conditions in the US (like the Yellowstone Supervolcano or the San Andreas Fault)” are targeted by those warheads, “such an attack guarantees the destruction of the US as a state and the entire transnational elite,” he said.

The production of around 40 or 50 such mega-warheads for ICBMs or extra-long-range torpedoes would make sure that at least a few of them reach their target no matter how a nuclear conflict between the US and Russia develops, the expert said.

Digging into Wikipedia a little bit, the largest nuclear weapon ever tested was in fact a 50-megaton bomb detonated by the USSR in 1961, and it was originally designed to be 100 megatons. The largest ever detonated by the US was 15 megaton device in 1954. It is worth noting thought that modern nuclear missiles can have 8 or more warheads attached to them.