Has there ever been a case where a politician used drugs to improve their performance in a debate? Well, according to a 2013 story in the New York Post:

The night of the first Kennedy-Nixon debate, Kennedy met with Jacobson just a few hours before he took the stage. The senator was “complaining in a voice barely above a whisper of extreme fatigue and lethargy,” the authors write. Jacobson plunged a needle “directly into Kennedy’s throat and pumped methamphetamine into his voice box.”

The result was clear within minutes, and an artificially energized Kennedy changed American history that night by upstaging Nixon.