Yes, the headline pretty much describes what this Wired article is about. The following things have happened:
- Pig hearts were genetically modified to reduce their odds of being rejected by human recipients.
- A genetically engineered pig heart was transplanted into a human being, who lived for 60 days. This was considered a success.
- Genetically modified pig kidneys were transplanted into a brain-dead person and the body was kept alive(?)/functioning for 77 hours.
- Genetically engineered pig hearts were transplanted into two “recently deceased” human bodies and kept beating for three days.
- It’s not clear from the article exactly when this happened, but a genetically modified pig heart was transplanted into a baboon and the baboon lived for over two years.
There are some obvious ethical questions here. The living human beings who took part in these studies were close to death and had no other viable options that would extend their lives, and I would assume that both they and the “recently deceased” individuals consented to the tests. And there are people dying every day because their organs fail before they get to the top of the transplant lists. I suppose I would let them use my recently deceased body in this way if it would help someone else. It seems a bit creepy, but to surgeons a human body is just a machine and they are mechanics. And after they shut down my pig heart or whatever, they could still use my body as a crash dummy. Or could they use dead bodies with functioning organs as crash dummies? There’s a disturbing thought, but if it would save the lives of people with actual brains and loved ones it would not be obviously unethical.
Now if we were writing a science fiction horror story, we could probably think of other places to go with this. Paul Macauley’s 1998 story collection The Invisible Country comes to mind. These are mind-blowing, disturbing stories about mistreatment of genetically engineered baboon-human hybrids who are kept as slaves, prostitutes, and worse. Using a deceased human body with no functioning brain for these purposes would be very creepy but less obviously unethical.