This article is subtitled “My Wish for 2023”, but it is mostly about what the Gates Foundation did in 2022. He says the world moved backward on polio, but it can and should be eradicated, and we know how to do it. Infant mortality in developing countries can be reduced by using cheap ultrasound machines powered run by smartphone apps to identify high-risk pregnancies, stretching the limited pool of medical expertise (and it seems like this sort of thing could save money in developed countries if it could be done at home in combination with a telehealth session, at a pharmacy or neighborhood clinic say in a school or library, by a technician showing up at your door at a convenient time, etc.) He is predicting a gene-therapy based cure for HIV in 10-15 years. He says a gene therapy based cure for sickle cell disease is available now, but prohibitively expensive or unavailable in developing countries where the disease is common.