Tag Archives: longevity

September 2015 in Review

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What did I learn in September? Let’s start with the bad and then go to the good.

Negative stories (-11):

  • The Environmental Kuznets Curve is the idea that a developing country will go through a period of environmental degradation caused by economic growth, but then the environment will improve in the long run. Sounds okay but the evidence for it is weak. (-1)
  • The Inca are an example of a very advanced civilization that was wiped out. (-1)
  • Consumerism and the pursuit of wealth are not sufficient cultural glue to hold a nation together. (-1)
  • Climate may be playing a role in the current refugee crisis, and the future may hold much more of this. (-1)
  • North and South America would have enormous herds of large mammals if humans had never come along.  (-1)
  • The U.S. clearly has lower average life expectancy than other advanced countries. Developing countries in Asia and Latin America are catching up, but life expectancy in Africa is still tragically low. (-1)
  • People get away with criminally violent behavior behind the wheel because police do not see it as on par with other types of crime. (-2)
  • People are still suggesting a false choice between critical and creative thinking. This is not how the problems are tomorrow will be solved. (-2)
  • This just in – an extreme form of central planning does not work. (-1)

Positive stories (+9):

    • Pneumatic chutes for garbage collection have been used successfully on an island in New York City for decades. This technology has some potential to move us closer to a closed loop world where resources are recovered rather than wasted. (+1)
    • Scientists and engineers could learn some lessons from marketing on how to communicate better with the rest of humanity. (+1)
    • There is new evidence from New Zealand on economic benefits of cycling and cycling infrastructure. (+1)
    • There has been some progress on New York City’s “lowline“, which is what a park in space might look like. The only problem is, it looks to me like a mall. I’ve said it before and I’ll say it again, the exciting science fiction future may look a lot like malls in space. (+0)
    • The U.S. Surgeon General thinks walkable communities may be a good idea. The End of Traffic may actually be a possibility. (+3)
    • Peter Singer advocates “effective altruism”. A version of his Princeton ethics course is available for free online. (+1)
    • Edward Tufte does not like Infographics. (+0)
    • The unpronounceable Mihaly Csikszentmihalyi believes he has found the key to happiness. (+1)
    • The right mix of variety and repetition might be the key to learning. (+1)

life expectancy

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NPR has a tabulation of life expectancy in hundreds of countries. What jumps out to me is that, outside of Africa, the gap between developed and developing countries is not all that great – most countries are in the 70s for men, and only a small handful (Andorra, Iceland, Israel, Japan) crack 80. Women consistently outlive men by a few years (Afghanistan and Zambia are the only two exceptions on the list, and Russia jumps out as a country where women outlive men by more than 10 years).

Just as a sample, here are the numbers for men in countries I have set foot in:

  • Australia: 79
  • Belgium: 77
  • Canada: 79
  • Indonesia: 68
  • Malaysia: 71
  • Netherlands: 78
  • Norway: 79
  • Singapore: 79
  • South Korea: 77
  • Sweden: 79
  • Thailand: 71
  • United Kingdom: 79
  • United States: 76

What accounts for the differences? I don’t know, but let me speculate. At first glance, national wealth seems to be an excellent predictor. But there are probably many nuances to the data. For example, infant mortality rates can make average life expectancy a little misleading. If the numbers were based instead on life expectancy for those who make it to age 5, they might be a little different. Don’t get me wrong, infant mortality is an awful thing, but the measures needed to reduce it are different from the measures needed to keep adults healthy. Beyond that, universal and affordable health care almost certainly plays a role in the list above (hello, U.S., you stand out clearly as the sickest rich country on this list). Diet, obesity, and smoking all must play a role.

August 2015 in Review

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Negative stories (-12):

  • About 7-19% of cancers are caused by chemicals in the environment. (-1)
  • Steven Hawking is worried about an artificial intelligence arms race starting “within years, not decades”. (-2)
  • The anti-urban attack continues, based on the false idea that crowded, stressful living conditions are the only type of urban living conditions available, and people are being forced into them against their will. This is naked, obvious propaganda that must be rejected. (-1)
  • The more ignorant our species is, the more confident we tend to feel. (-3)
  • According to Naomi Klein, “Our economic system and our planetary system are now at war.”  In related news, July was the warmest month ever recorded by humans, and carbon dioxide concentrations are the highest seen for millions of years. (-3)
  • The media buzz about a worldwide recession seems to be increasing. (-2)

Positive stories (+12):

  • The suburban vs. urban culture wars continue. Suburban office parks are tanking as young people prefer more urban job settings. Entrepreneurs are working on the problems of being car-less with children. (+1)
  • Steven Hawking has a plan to figure out if there is any intelligent life out there. (+1)
  • There are straightforward, practical ideas for dealing with the issues of loading, deliveries, and temporary contractor parking in dense urban areas. (+1)
  • Economists have concluded that preventing human extinction may be economical after all, because “reducing an infinite loss is infinitely profitable”. Is this kind of thinking really useful? (+0)
  • “gene drive” technology helps make sure that genetically engineered traits are passed along to offspring. (+0)
  • Technology marches on – quantum computing is in early emergence, the “internet of things” is arriving at the “peak of inflated expectations”, big data is crashing into the “trough of disillusionment”, virtual reality is beginning its assent to the “plateau of productivity”, and speech recognition is arriving on the plateau. And super-intelligent rodents may be on the way. (+1)
  • Honeybees may be in trouble, but they are not the only bees. (+0)
  • Robotics may be on the verge of a Cambrian explosion, which will almost certainly be bad for some types of jobs, but will also bring us things like cars that avoid pedestrians and computer chips powered by sweat. I for one am excited to be alive at this moment in history. (+2)
  • Dogs can be trained to smell cancer. (+1)
  •  There’s promise of a vaccine for MERS. (+1)
  • It may be possible to capture atmospheric carbon and turn it into high-strength, valuable carbon fiber. This sounds like a potential game-changer to me, because if carbon fiber were cheap it could be substituted for a lot of heavy, toxic and energy-intensive materials we use now, and open up possibilities for entirely new types of structures and vehicles. (+3)
  • Robot deliveries and reusable containers could be a match. (+1)

You might think I rigged that to come out even, but I didn’t.

chemicals and cancer

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I’ve tended not to obsess over chemicals and cancer, because I think there are other risks that are much higher and much more clearly proven (like the high odds of death every time you set foot in or anywhere near a motor vehicle, to give one example.) I also tend to accept some chemicals, like water disinfectants, food preservatives, drugs, even pesticides, as somewhat necessary evils – we actually know they have a downside, but they do more good than harm on balance. In a sense, it is a “luxury” that many of us avoid violence and infectious diseases long enough to get old and die of cancer. Cancer is at least to some extent a random phenomenon. That doesn’t mean we shouldn’t be looking for safer alternatives to these chemicals that do the same good. If we don’t look we won’t find them. And then, there are chemicals that are known to be harmful, and have no positive effects. Triclosan comes to mind. The companies using cynical fear-based marketing to force these on people should be punished.

All that aside, our food, water, air, and consumer products are full of chemicals, with the result that our bodies are full of chemicals. We don’t have good information on what most of them are doing to us, and especially what combinations of them may be doing to us. Here’s an interesting article that estimates what fraction of cancers are caused by chemicals in the environment, as opposed to lifestyle choices, genetics, and plain old bad luck.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

May 2015 in Review

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Negative stories:

  • MIT says there is a critical long term decline in U.S. research and development spending, while spending is increasing in many other parts of the world.
  • Lake Mead, water supply for Las Vegas and several other major western U.S. cities, is continuing to dry up. The normal snowpack in Washington State is almost completely absent, while much of Oregon has declared a state of emergency. As the drought grinds on, recycled water (sometimes derided as “toilet to tap”) is becoming more common in Calfornia. This is not bad in itself – on the contrary it is an example of technological adaptation and closing the loop. It does have a cost in money and energy though, which are resources that are then not available for other things like education or infrastructure or whatever people need. In other words, drought makes us all a little bit poorer.
  • We’ve hit 400 ppm carbon dioxide in the atmosphere, not just some places sometimes but pretty much everywhere, all the time.
  • There may be a “global shortage of aggregate demand“, and most countries are not dealing with it well. In many developed countries, increases in average longevity could lead to a trend of long-term deflation. This could eventually happen in almost all countries.
  • Climate change is going to make extreme weather more frequent and more damaging in U.S. cities. The 2015 El Nino could break records.
  • There just isn’t a lot of positivity or hope for better passenger rail service in the U.S.
  • Human chemical use to combat diseases, bugs, and weeds is causing the diseases, bugs and weeds to evolve fast.
  • Unfortunately there is no foolproof formula to make education work.

Positive stories:

  • Less leisure time could mean less sustainable outcomes, because people just have less time to think and act on their good intentions. I’m putting this in the positive column because although people in the U.S. and many other countries still work long hours, the trend so far is less work and more wealth for human population as a whole over very long periods of time. Obviously the transition is not smooth or painless for all workers all of the time.
  • I found a nice example of meta-analysis, which aggregates findings of a large number of scientific and not-so-scientific studies in a useful form, in this case in the urban planning field.
  • May is time to pull on the urban gardening gloves.
  • Melbourne’s climate change adaptation plan focuses on green open space and urban tree canopy.
  • Painless vaccines may be on the way.
  • The rhetoric on renewable energy is really changing as it starts to seriously challenge fossil fuels on economic grounds. Following the Fukushima disaster, when all Japan’s nuclear reactors were shut down, the gap was made up largely with liquid natural gas and with almost no disruption of consumer service. But renewables also grew explosively. Some are suggesting Saudi Arabia is supporting lower oil prices in part to stay competitive with renewables. Wind and solar capacity are growing quickly in many parts of the world. Lester Brown says the tide has turned and renewables are now unstoppable.
  • Commercial autonomous trucks are here.
  • The UK may have hit “peak car“.
  • Seattle is allowing developers to provide car share memberships and transit passes in lieu of parking spaces.

aging and deflation

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This study says the relationship between aging and deflation (as seen in Japan, but possibly coming to many more countries in the future) depends on whether the aging is driven by falling fertility (which shrinks the work force in absolute terms) or longevity (which shrinks it only in relative terms).

Negative correlations between inflation and demographic aging were observed across developed nations recently. To understand the phenomenon from a politico-economic perspective, we embed the fiscal theory of the price level into an overlapping-generations model. In the model, successive short-lived governments choose income tax rates and bond issues considering the political influence of existing generations and the policy response of future governments. The model sheds new light on the traditional debate about the burden of national debt. Because of price adjustments, the accumulation of government debt does not become a burden on future generations. Our analysis reveals that the effects of aging depend on its causes. Aging is deflationary when caused by an increase in longevity but inflationary when caused by a decline in birth rate. Numerical simulation shows that aging over the past 40 years in Japan generated deflation of about 0.6 percentage points annually.
Here is another study that concludes “a larger share of dependents (ie young and old) is correlated with higher inflation, while a larger share of working age cohorts is correlated with lower inflation.” So maybe it depends to what extent the aging population is dependent on the working population, and whether the working population has additional dependents in the form of children (who will become the next working population). It’s complex, dynamic stuff that is hard to puzzle out.

April 2015 in Review

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Negative stories:

Positive stories:

  • Mr. Money Mustache brought us a nice post on home energy efficiency projects. This was a very popular post.
  • Biotechnology may soon bring us the tools to seriously monkey with photosynthesis. (This is one of those stories where I struggle between the positive and negative columns, but clearly there is a potential upside when we will have so many mouths to feed.)
  • Donald Shoup, author of The High Cost of Free Parking, is retiring. That might sound bad, but his ground-breaking ideas are continuing on and actually seem to be going mainstream.
  • Lee Kuan Yew, who took Singapore “from third world to first” in one generation, passed away (in March, but I wrote about it in April. Let me be clear – I am an admirer and it is his life I am putting in the positive column, not his death.)
  • Donella Meadows explained how your bathtub is a dynamic system.
  • Robert Gordon offers a clear policy prescription for the U.S. to support continued economic growth.
  • I explain how a cap-and-trade program for stormwater and pollution producing pavement could work.
  • Joel Mokyr talks about advances in information technology, materials science and biotechnology.
  • Some U.S. cities are fairly serious about planting trees.
  • Edmonton has set a target of zero solid waste.
  • Saving water also saves energy. It’s highly logical, but if you are the skeptical type then here are some numbers. Also, urban agriculture reduces carbon emissions.
  • Peter Thiel thinks we can live forever. (positive, but do see my earlier comment about mouths to feed…)
  • A paper in Ecological Economics tries to unify the ecological footprint and planetary boundary concepts.
  • Philadelphia finally has bike share.

Peter Thiel and immortality

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Logic and history suggest that getting your hopes up about immortality is a path to disappointment. Nonetheless, here is a fun Washington Post article about Peter Thiel and friends who believe otherwise.

“If you think you can only do very little and be very incremental, then you’ll work only on very incremental things. It’s self-fulfilling,” Thiel, who is 47 and estimated to be worth $2.2 billion, said in an interview. “It’s those who have an optimism about what can be done that will shape the future.”

He and the tech titans who founded Google, Facebook, eBay, Napster and Netscape are using their billions to rewrite the nation’s science agenda and transform biomedical research. Their objective is to use the tools of technology — the chips, software programs, algorithms and big data they used in creating an information revolution — to understand and upgrade what they consider to be the most complicated piece of machinery in existence: the human body.

The entrepreneurs are driven by a certitude that rebuilding, regenerating and reprogramming patients’ organs, limbs, cells and DNA will enable people to live longer and better. The work they are funding includes hunting for the secrets of living organisms with insanely long lives, engineering microscopic nanobots that can fix your body from the inside out, figuring out how to reprogram the DNA you were born with, and exploring ways to digitize your brain based on the theory that your mind could live long after your body expires.

gene editing

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Here is a long article in MIT Technology Review about gene editing.

“Germ line” is biologists’ jargon for the egg and sperm, which combine to form an embryo. By editing the DNA of these cells or the embryo itself, it could be possible to correct disease genes and to pass those genetic fixes on to future generations. Such a technology could be used to rid families of scourges like cystic fibrosis. It might also be possible to install genes that offer lifelong protection against infection, Alzheimer’s, and, Yang told me, maybe the effects of aging. These would be history-making medical advances that could be as important to this century as vaccines were to the last.

That’s the promise. The fear is that germ-line engineering is a path toward a dystopia of superpeople and designer babies for those who can afford it. Want a child with blue eyes and blond hair? Why not design a highly intelligent group of people who could be tomorrow’s leaders and scientists?…

All this means that germ-line engineering is much farther along than anyone imagined. “What you are talking about is a major issue for all humanity,” says Merle Berger, one of the founders of Boston IVF, a network of fertility clinics that is among the largest in the world and helps more than a thousand women get pregnant each year. “It would be the biggest thing that ever happened in our field,” he says. Berger predicts that repairing genes for serious inherited disease will win wide public acceptance, but beyond that, the technology would cause a public uproar because “everyone would want the perfect child” and it could lead to picking and choosing eye color and eventually intelligence. “These are things we talk about all the time,” he says. “But we have never had the opportunity to do it.”

How far out are practical applications in humans? Reading farther down, some are saying 10-20 years.