Tag Archives: drugs

Holmes and cocaine

Still reading some of the early Sherlock Holmes stuff (I’ve moved on to The Sign of the Four), I’m a little surprised by descriptions of his drug use. The implication is that his brain had no “off” switch. He had to be always thinking and analyzing. Human relations really held no interest for him. Mental idleness led to extreme depression, which he would temporarily self-treat with drugs, music, or a combination of the two. I’m nowhere near this extreme, and I’m not into drugs, but I can sympathize somewhat. I am more interested in quiet contemplation, and less interested in spending time with other human beings, than the average person, I think. I don’t dabble in drugs (because I am interested in living for a long time) but I definitely enjoy a good stiff drink as a way to maximize the recharging power of my alone time.

Sherlock Holmes took his bottle from the corner of the mantel-piece and his hypodermic syringe from its neat morocco case. With his long, white, nervous fingers he adjusted the delicate needle, and rolled back his left shirt-cuff. For some little time his eyes rested thoughtfully upon the sinewy forearm and wrist all dotted and scarred with innumerable puncture-marks. Finally he thrust the sharp point home, pressed down the tiny piston, and sank back into the velvet-lined arm-chair with a long sigh of satisfaction.

Three times a day for many months I had witnessed this performance, but custom had not reconciled my mind to it. On the contrary, from day to day I had become more irritable at the sight, and my conscience swelled nightly within me at the thought that I had lacked the courage to protest. Again and again I had registered a vow that I should deliver my soul upon the subject, but there was that in the cool, nonchalant air of my companion which made him the last man with whom one would care to take anything approaching to a liberty. His great powers, his masterly manner, and the experience which I had had of his many extraordinary qualities, all made me diffident and backward in crossing him.

Yet upon that afternoon, whether it was the Beaune which I had taken with my lunch, or the additional exasperation produced by the extreme deliberation of his manner, I suddenly felt that I could hold out no longer.

“Which is it to-day?” I asked,—”morphine or cocaine?”

He raised his eyes languidly from the old black-letter volume which he had opened. “It is cocaine,” he said,—”a seven-per-cent. solution. Would you care to try it?”

“No, indeed,” I answered, brusquely. “My constitution has not got over the Afghan campaign yet. I cannot afford to throw any extra strain upon it.”

He smiled at my vehemence. “Perhaps you are right, Watson,” he said. “I suppose that its influence is physically a bad one. I find it, however, so transcendently stimulating and clarifying to the mind that its secondary action is a matter of small moment.”

“But consider!” I said, earnestly. “Count the cost! Your brain may, as you say, be roused and excited, but it is a pathological and morbid process, which involves increased tissue-change and may at last leave a permanent weakness. You know, too, what a black reaction comes upon you. Surely the game is hardly worth the candle. Why should you, for a mere passing pleasure, risk the loss of those great powers with which you have been endowed? Remember that I speak not only as one comrade to another, but as a medical man to one for whose constitution he is to some extent answerable.”

He did not seem offended. On the contrary, he put his finger-tips together and leaned his elbows on the arms of his chair, like one who has a relish for conversation.

“My mind,” he said, “rebels at stagnation. Give me problems, give me work, give me the most abstruse cryptogram or the most intricate analysis, and I am in my own proper atmosphere. I can dispense then with artificial stimulants. But I abhor the dull routine of existence. I crave for mental exaltation.

what’s new with drugs

Drugs are not immune from the current wave of seemingly accelerating innovation (from Pacific Standard Magazine):

New psychoactive substances are coming out so quickly that it’s not possible to ban them fast enough to keep up, let alone police or scientifically understand them. When one substance is outlawed, another is born, just chemically distinct enough from the last one to evade its ban…

Not since the 19th century—when an earlier wave of globalization rapidly accelerated the spread of opium, cocaine, marijuana, and hazily defined “patent medicines”—has there been such a burgeoning and unregulated pharmacopeia. And by all indications, the future promises only more acceleration. Last year, a research lab at Stanford demonstrated that it’s possible to produce opioid drugs like morphine using a genetically modified form of baker’s yeast. Soon, even the production of traditional illegal drugs or illicit versions of pharmaceuticals could become a highly decentralized cottage industry, posing the same kind of regulatory challenge that the specter of 3-D printed firearms poses to the project of gun control.

In 2013, the U.N.’s World Drug Report summed up the global situation this way: “The international drug control system is floundering, for the first time, under the speed and creativity of the phenomenon known as new psychoactive substances.” Testifying before Congress that same year, the DEA’s Joseph Rannazzisi said that his agency could not keep up with “the clandestine chemists and traffickers who quickly and easily replace newly controlled substances with new, non-controlled substances.”

New Zealand is starting to regulate recreational drugs more like food: with labeling, consumer notices, and so on. Sometimes I wonder how long this will stay a mom and pop business – once it’s legal, won’t big drug and chemical companies try to get in on the game? It’s a brave new world.