Tag Archives: drugs

November 2018 in Review

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Most frightening and/or depressing stories:

  • Coral reefs are expected to decline 70-90% by mid-century.
  • The U.S. stock market is overvalued by about 40% by historic measures, and some economists think a major recession may be looming.
  • About half a million people have been killed in Iraq, Afghanistan, and Pakistan since the U.S. invasions starting in 2001. This includes only people killed directly by violence, not disease, hunger, thirst, etc.

Most hopeful stories:

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

  • New tech roundup: People in Sweden are barely using cash at all, and some are paying with microchips embedded in their fingers. New technology may allow screening of multiple airport passengers from 25 feet away with minimal disruption. This is great for airline passengers who are already expecting to be screened intrusively, but of course raises some concerns about potential uses elsewhere in the public realm. Amazon is hiring about 100,000 seasonal workers this year, compared to about 120,000 in past years, and the difference may be explained by automation. There is a new ISO standard for toilets not connected to sewers systems (and not just your grandfather’s septic tank.)
  • A unidentified flying object has been spotted in our solar system, and serious scientists say there is at least a plausible, if very unlikely, chance that it is an alien spacecraft.
  • People are taking micro doses of LSD on a daily basis, believing it boosts creativity, and there is some evidence for this although the science is not rigorous.

microdosing

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There are people taking small doses of LSD and other psychedelics every day for their possible/suspected health benefits, and there may actually be some science behind this.

Microdosing psychedelics – the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin – is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-distorting properties, microdosing may provide complementary clinical benefits using lower-risk, non-hallucinogenic doses. No experimental study has evaluated psychedelic microdosing, however; this pre-registered study is the first to investigate microdosing psychedelics and mental health. Recruited from online forums, current and former microdosers scored lower on measures of dysfunctional attitudes and negative emotionality and higher on wisdom, open-mindedness, and creativity when compared to non microdosing controls. These findings provide promising initial evidence that warrants controlled experimental research to directly test safety and clinical efficacy. As microdoses are easier to administer than full-doses, this new paradigm has the exciting potential to shape future psychedelic research.

smart drugs

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This BBC article talks about how some people are using amphetamines like Adderall and Ritalin to stay focused and motivated in high pressure jobs. It clearly works, at least for short periods of time. It is not clear whether it can work longer term, because people may either need a significant recovery period to recover from use of the drugs, during which they are less focused and motivated than normal, or else they may become addicted to the drugs. But the article also points out that the new drugs are not qualitatively different from using coffee to stay focused and productive – it is just a matter of differences in degree and chemistry, and coffee has proven to be safe and even beneficial to most people.

psychedelics, the cure for…everything?

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Serious research suggests psychedelics may be an effective cure for depression, anxiety, post-traumatic stress, and addiction, among other things. This article also compares reported experiences under psychedelics to meditation, which I found interesting.

What is happening when a person meditates? If you meditate in a dedicated way, for long enough, most people say that they start to experience a spiritual change. Why did meditation make people feel they were being changed in a way that was mystical — and what did that even mean? He stumbled across the psychedelics studies from the 1960s, and it seemed to him that the way people described feeling when they took psychedelics was very similar to the way people described when they were in a state of deep meditation. He began to wonder if they were, in some strange sense, two different ways of approaching the same insight. Could investigating one unlock the secrets of the other? …

When you take a psychedelic, most people will have a spiritual experience – you get a sense that your ego-walls have been lowered, and you are deeply connected to the people around you, to our whole species, to the natural world, to existence. But it turns out the intensity of the spiritual experience varies from person to person. For some people, it will be incredibly intense; for some people, mild; and some people have no spiritual experience at all. At Johns Hopkins, the team discovered that many of the positive effects correlate very closely with the intensity of the spiritual experience. So if you had a super-charged spiritual experience, you got the benefits very heavily; and if you had no spiritual experience, you didn’t have many positive effects.

Okay, I don’t usually go here, but let’s say just for the sake of argument that religion is not objectively true. Then these spiritual experiences people tend to have while under the effects of drugs, meditation, and prayer actually come from inside us, are baked into our minds in some way. And maybe people who have more of them really are happier and better off, which would seem to be a good thing maybe even if they are not objectively true.

U.S. life expectancy down again

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The U.S. Centers for Disease Control has released statistics on life expectancy and causes of death for 2016. Some interesting findings:

  • Overall average life expectancy fell by 0.1 year, from 78.7 to 78.6 years.
  • The average masks the finding that for women, life expectancy held steady at 81.1 years while for men, it decreased by 0.2 years from 76.3 to 76.1 years.
  • Deaths from disease were down in almost every category. The increases come from “unintentional injury” and suicide. Unintentional injury sounds like car accidents and falling off a ladder, and it does include those things. But dig a little bit and it includes “poisoning”, and poisoning in turn includes drug overdose.

The Guardian explains that life expectancy has fallen two years in a row and how unusual that is:

Drug overdoses killed 63,600 Americans in 2016, an increase of 21% over the previous year, researchers at the National Center for Health Statistics found.

Americans can now expect to live 78.6 years, a decrease of 0.1 years. The US last experienced two years’ decline in a row in 1963, during the height of the tobacco epidemic and amid a wave of flu.

“We do occasionally see a one-year dip, even that doesn’t happen that often, but two years in a row is quite striking,” said Robert Anderson, chief of the mortality statistics branch with the National Center for Health Statistics. “And the key driver of that is the increase in drug overdose mortality.”

The article goes on to explain that the last time we saw three years of decline was during the Spanish flu epidemic 100 years ago.

Comparing any two years could easily be a statistical blip, as any climate science denier could tell you. But it seems clear that over time the U.S. is losing ground to its peers in the developed world. The solution our elected politicians have identified, of course, is to take away health care and mental health coverage from the working class.

FDA has approved trials of Ecstasy to treat post-traumatic stress disorder

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This is according to Science:

In people with PTSD, a small sensory trigger such as a sound or a smell can bring a traumatic memory rushing back. “The disabling element of PTSD is the fact that when the memory starts, the emotions completely override you and overwhelm the brain,” Nutt says. Studies suggest that MDMA can dampen the emotional response to the memory, allowing people to relive their trauma and work through it, he says. The MDMA-treatment consists of several sessions of psychotherapy, some conducted while the patient is under the influence of the drug…

A small U.S. study that first suggested MDMA could help treat PTSD was published in 2011. Since then, researchers in Canada, Israel, and the United States have jointly carried out larger phase II trials funded by MAPS; their results, which remain unpublished but have been reviewed by the FDA, were very good, says Doblin. Overall, 107 participants who had suffered from PTSD for an average of 17.8 years were treated in the phase II trials, Doblin says. Of the 90 patients who were available to be studied 12 months later, 61 no longer had PTSD.

In late July, says Doblin, MAPS and FDA agreed on how the coming phase III trials—usually the last hurdle before seeking a drug’s approval from regulators—should be conducted.

910 drug overdose deaths in Philadelphia last year

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910 deaths from drug overdoses last year. That’s the depressing stat in the video below. This is a way bigger problem than homicides (278 in 2016).

To put this number in a little more context, I looked up some statistics on all causes of death in Philadelphia – the most recent year I could find was 2015. Here are a few highlights:

  • “diseases of heart”: 3,418
  • “nontransport accidents”: 823 (I imagine this includes everything from drowning to falling off a ladder to kids playing with guns – it’s a surprisingly large number of people, but possibly also the hardest category to do something about)
  • “diabetes mellitus”: 365
  • homicide: 291
  • “intentional self harm (suicide)”: 160 (the teen rate is relatively low, then suicides reach a pretty steady rate for people in their 20s through 50s)
  • “motor vehicle accidents”: 98 (I’m surprised this isn’t higher, but still, most of these should be preventable. It doesn’t tell us how many of these are pedestrians and bicyclists.)
  • HIV: 67 (the majority are deaths are people in their 50s and 60s)
  • “all other causes”: 2,542

It’s not that I enjoy thinking about death. But if you were looking for public policies to help people and politics and institutional baggage were not issues, you would look at the causes that kill the most people the youngest, and the ones where policy is likely to have the greatest impact. Getting people on maintenance medications to control blood pressure, diabetes, and cholesterol is obviously important – perhaps some sort of universal health care program could be considered. Dealing with drug overdoses and the underlying economic and mental health issues would be crucial. Dealing with mental health in a serious way would also help with the suicide problem.

opioid law suits

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The Ohio attorney general is suing pharmaceutical companies over their role in the opioid crisis. Who knows if it goes anywhere, but if it does I can imagine this being as big as the tabacco lawsuits, and eventually every state will want a piece. In other words, the argument would be that massive highly profitable companies are making their profits by killing their customers, are well aware of it, and are hiding it. Unlike cigarettes though, there are clearly legitimate uses of the drugs, they are prescribed by doctors, and there are all kinds of warnings printed on the labels.

This also reminded me of the very long expose from the LA Times called Oxycontin’s 12-Hour Problem. I admit I haven’t read the whole thing, but the basic problem is they tell people in excruciating pain the drug will work for 12 hours, only it doesn’t, so they take it more often to help with the excruciating pain, but it is only safe to take it every 12 hours.

new studies about drugs

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Here are a bunch of new studies on drugs, both legal and illegal. Now, I am not advocating drug use. I am just advocating being aware of scientific research and making responsible decisions that reflect one’s personal risk tolerance. I would also point out that some legal drugs, like alcohol, tobacco, and prescription pain killers, are absolutely proven to cause harm to a lot of people, while some illegal drugs are not. I don’t take illegal drugs personally, because the idea of not knowing where they came from or what is in them is too scary for me. Nonetheless, here we go.

Recent studies have found that:

  • There is no association between marijuana use and heart disease.
  • There is a strong association between common pain killers, including ibuprofen, and heart disease, in “high doses”. I do not know if high doses include the Extra Strength Advil I can buy over the counter.
  • There is no clear link between marijuana use by pregnant women and any adverse effects on babies, although there is the “theoretical potential“. There is a strong link between alcohol and adverse effects on babies – I won’t even bother citing studies, they are easy to find.
  • “Magic mushrooms” are considered nontoxic, but they can have profound psychological effects. People who already have suicidal tendencies somewhat frequently attempt suicide while taking them, which is disturbing.

So I think there are pretty clear reasons to support medical use of marijuana and hallucinogens, and any side effects of recreational use should probably be treated as social or medical problems rather than law enforcement ones. I wouldn’t be surprised to see a gradual trend toward legalization, and eventual co-opting of access to these drugs by the mainstream government and corporate world. And next time I have a headache, I think I will just drink a glass of wine and go to bed rather than reaching for the ibuprofen bottle.