Tag Archives: biotechnology

2021: Year in Review

As per usual, I’ll list out and link to the stories I chose as the most frightening, most hopeful, and most interesting each month in 2021. Then I’ll see if I have anything smart to say about how it all fits together.

Survey of the Year’s Stories and Themes

Most frightening and/or depressing stories:

  • JANUARY: A China-Taiwan military conflict is a potential start-of-World-War-III scenario. This could happen today, or this year, or never. Let’s hope for the latter. This is a near-term existential risk, but I have to break my own “rule of one” and give honorable mention to two longer-term scary things: crashing sperm counts and the climate change/fascism/genocide nexus.
  • FEBRUARY: For people who just don’t care that much about plants and animals, the elevator pitch on climate change is it is coming for our houses and it is coming for our food and water.
  • MARCH: In the U.S. upper Midwest (I don’t know if this region is better or worse than the country as a whole, or why they picked it), electric blackouts average 92 minutes per year, versus 4 minutes per year in Japan.
  • APRIL: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.
  • MAY: The Colorado River basin is drying out.
  • JUNE: For every 2 people who died of Covid-19 in the U.S. about 1 additional person died of indirect effects, such as our lack of a functioning health care system and safe streets compared to virtually all our peer countries.
  • JULY: The western-U.S. megadrought looks like it is settling in for the long haul.
  • AUGUST: The U.S. is not prepared for megadisasters. Pandemics, just to cite one example. War and climate change tipping points, just to cite two others. Solutions or at least risk mitigation measures exist, such as getting a health care system, joining the worldwide effort to deal with carbon emissions, and as for war, how about just try to avoid it?
  • SEPTEMBER: The most frightening climate change tipping points may not be the ones we hear the most about in the media (at least in my case, I was most aware of melting ice sheets in Greenland and Antarctica, collapse of ocean circulation patterns). The most damaging may be melting permafrost on land and methane hydrates underwater, both of which contain enormous amounts of methane which could set off a catastrophic and unstoppable feedback loop if released in large quantities.
  • OCTOBER: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.
  • NOVEMBER: Freakonomics podcast explained that there is a strong connection between cars and violence in the United States. Because cars kill and injure people on a massive scale, they led to an expansion of police power. Police and ordinary citizens started coming into contact much more often than they had. We have no national ID system so the poor and disadvantaged often have no ID when they get stopped. Everyone has guns and everyone is jumpy. Known solutions (safe street design) and near term solutions (computer-controlled vehicles?) exist, but are we going to pursue them as a society? I guess I am feeling frightened and/or depressed today, hence my choice of category here.
  • DECEMBER: Mass migration driven by climate change-triggered disasters could be the emerging big issue for 2022 and beyond. Geopolitical instability is a likely result, not to mention enormous human suffering.

Most hopeful stories:

  • JANUARY: Computer modeling, done well, can inform decisions better than data analysis alone. An obvious statement? Well, maybe to some but it is disputed every day by others, especially staff at some government regulatory agencies I interact with.
  • FEBRUARY: It is possible that mRNA technology could cure or prevent herpes, malaria, flu, sickle cell anemia, cancer, HIV, Zika and Ebola (and obviously coronavirus). With flu and coronavirus, it may become possible to design a single shot that would protect against thousands of strains. It could also be used for nefarious purposes, and to protect against that are ideas about what a biological threat surveillance system could look like.
  • MARCH: I officially released my infrastructure plan for America, a few weeks before Joe Biden released his. None of the Sunday morning talk shows has called me to discuss so far. Unfortunately, I do not have the resources of the U.S. Treasury or Federal Reserve available to me. Of course, neither does he unless he can convince Congress to go along with at least some portion of his plans. Looking at his proposal, I think he is proposing to direct the fire hoses at the right fires (children, education, research, water, the electric grid and electric vehicles, maintenance of highways and roads, housing, and ecosystems. There is still no real planning involved, because planning needs to be done in between crises and it never is. Still, I think it is a good proposal that will pay off economically while helping real people, and I hope a substantial portion of it survives.
  • APRIL: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.
  • MAY: An effective vaccine for malaria may be on the way. Malaria kills more children in Africa every year than Covid-19 killed people of all ages in Africa during the worst year of the pandemic. And malaria has been killing children every year for centuries and will continue long after Covid-19 is gone unless something is done.
  • JUNE: Masks, ventilation, and filtration work pretty well to prevent Covid transmission in schools. We should learn something from this and start designing much healthier schools and offices going forward. Design good ventilation and filtration into all buildings with lots of people in them. We will be healthier all the time and readier for the next pandemic. Then masks can be slapped on as a last layer of defense. Enough with the plexiglass, it’s just stupid and it’s time for it to go.
  • JULY: A new Lyme disease vaccine may be on the horizon (if you’re a human – if you are a dog, talk to your owner about getting the approved vaccine today.) I admit, I had to stretch a bit to find a positive story this month.
  • AUGUST: The Nordic welfare model works by providing excellent benefits to the middle class, which builds the public and political support to collect sufficient taxes to provide the benefits, and so on in a virtuous cycle. This is not a hopeful story for the U.S., where wealthy and powerful interests easily break the cycle with anti-tax propaganda, which ensure benefits are underfunded, inadequate, available only to the poor, and resented by middle class tax payers.
  • SEPTEMBER: Space-based solar power could finally be in our realistic near-term future. I would probably put this in the “interesting” rather than “hopeful” category most months, but I really struggled to come up with a hopeful story this month. I am at least a tiny bit hopeful this could be the “killer app” that gets humanity over the “dirty and scarce” energy hump once and for all, and lets us move on to the next layer of problems.
  • OCTOBER: The situation with fish and overfishing is actually much better than I thought.
  • NOVEMBER: Urban areas may have some ecological value after all.
  • DECEMBER: Covid-19 seems to be “disappearing” in Japan, or at least was before the Omicron wave. Maybe lessons could be learned. It seems possible that East Asian people have at least some genetic defenses over what other ethnic groups have, but I would put my money on tight border screening and an excellent public health care system. Okay, now I’m starting to feel a bit depressed again, sitting here in the U.S. where we can’t have these nice things thanks to our ignorant politicians.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

  • JANUARY: There have been fabulous advances in note taking techniques! Well, not really, but there are some time honored techniques out there that could be new and beneficial for many people to learn, and I think this is an underappreciated productivity and innovation skill that could benefit people in a lot of areas, not just students.
  • FEBRUARY: At least one serious scientist is arguing that Oumuamua was only the tip of an iceberg of extraterrestrial objects we should expect to see going forward.
  • MARCH: One study says 1-2 days per week is a sweet spot for working from home in terms of a positive economic contribution at the national scale. I think it is about right psychologically for many people too. However, this was a very theoretical simulation, and other studies attempting to measure this at the individual or firm scale have come up with a 20-50% loss in productivity. I think the jury is still out on this one, but I know from personal experience that people need to interact and communicate regularly for teams to be productive, and some people require more supervision than others, and I don’t think technology is a perfect substitute for doing these things in person so far.
  • APRIL: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.
  • MAY: I learned about Lawrence Kohlberg, who had some ideas on the use of moral dilemmas in education.
  • JUNE: The big U.S. government UFO report was a dud. But what’s interesting about it is that we have all quietly seemed to have accepted that something is going on, even if we have no idea what it is, and this is new.
  • JULY: “Cliodynamics” is an attempt at a structured, evidence-based way to test hypotheses about history.
  • AUGUST: Ectogenesis is an idea for colonizing other planets that involves freezing embryos and putting them on a spaceship along with robots to thaw them out and raise them. Fungi could also be very useful in space, providing food, medicine, and building materials.
  • SEPTEMBER: Philip K. Dick was not only a prolific science fiction author, he also developed a comprehensive theory of religion which could possibly even be the right one. Also, possibly related but not really, if there are aliens out there they might live in creepy colonies or super-organisms like ants or termites.
  • OCTOBER: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?
  • NOVEMBER: Peter Turchin continues his project to empirically test history. In this article, he says the evidence points to innovation in military technologies being driven by “world population size, connectivity between geographical areas of innovation and adoption, and critical enabling technological advances, such as iron metallurgy and horse riding“. What does not drive innovation? “state-level factors such as polity population, territorial size, or governance sophistication“. As far as the technologies coming down the pike in 2022, one “horizon scan” has identified “satellite megaconstellations, deep sea mining, floating photovoltaics, long-distance wireless energy, and ammonia as a fuel source”.
  • DECEMBER: Time reminded us of all the industries Elon Musk has disrupted so far: human-controlled, internal-combustion-fueled automobiles; spaceflight; infrastructure construction (I don’t know that he has really achieved any paradigm shifts here, but not for lack of trying), “artificial intelligence, neurotechnology, payment systems and cryptocurrency.” I’m not sure I follow a couple of these, but I think they missed satellites.

Continuing Signs of U.S. Relative Decline

Signs of U.S. decline relative to our peer group of advanced nations are all around us. I don’t know that we are in absolute decline, but I think we are now below average among the most advanced countries in the world. We are not investing in the infrastructure needed in a modern economy just to reduce friction and let the economy function. The annual length of electric blackouts in the U.S. (hours) compared to leading peers like Japan (minutes) is just one telling indicator. In March, I looked at the Build Back Better proposal and concluded that it was more like directing a firehose of money at a range of problems than an actual plan, but I hoped at least some of it would happen. My rather low but not zero expectations were met, as some limited funding was provided for “hard infrastructure” and energy/emissions projects, but little or nothing (so far, as I write this) to address our systemic failures in health care, child care, or education. The crazy violence on our streets, both gun-related and motor vehicle-related, is another indicator. Known solutions to all these problems exist and are being implemented to various extents by peer countries. Meanwhile our toxic politics and general ignorance continue to hold us back. Biden really gave it his best shot – but if this is our “once in a generation” attempt, we are headed down a road where we will no longer qualify as a member of the pack of elite countries, let alone its leader.

The Climate Change, Drought, Food, Natural Disaster, Migration and Geopolitical Instability Nexus

2021 was a pretty bad year for storms, fires, floods, and droughts. All these things affect our homes, our infrastructure, our food supply, and our water supply. Drought in particular can trigger mass migration. Mass migration can be a disaster for human rights and human dignity in and of itself, and managing it effectively is difficult even for well-intentioned governments. But an insidious related problem is that migration pressure can tend to fuel right wing populist and racist political movements. We see this happening all over the world, and the situation seems likely to get worse.

Tipping Points and other Really Bad Things We Aren’t Prepared For

We can be thankful that nothing really big and new and bad happened in 2021. My apologies to anyone reading this who lost someone or had a tough year. Of course, plenty of bad things happened to good people, and plenty of bad things happened on a regional or local scale. But while Covid-19 ground on and plenty of local and regional-scale natural disasters and conflicts occurred, there were no new planetary-scale disasters. This is good because humanity has had enough trouble dealing with Covid-19, and another major disaster hitting at the same time could be the one that brings our civilization to the breaking point.

So we have a trend of food insecurity and migration pressure creeping up on us over time, and we are not handling it well even given time to do so. Maybe we can hope that some adjustments will be made there to get the world on a sustainable track. Even if we do that, there are some really bad things that could happen suddenly. Catastrophic war is an obvious one. A truly catastrophic pandemic is another (as opposed to the moderately disastrous pandemic we have just gone through.) Creeping loss of human fertility is one that is not getting much attention, but this seems like an existential risk if it were to cross some threshold where suddenly the global population starts to drop quickly and we can’t do anything about it. Asteroids were one thing I really thought we didn’t have to worry much about on the time scale of any human alive today, but I may have been wrong about that. And finally, the most horrifying risk to me in the list above is the idea of an accelerating, runaway feedback loop of methane release from thawing permafrost or underwater methane hydrates.

We are almost certainly not managing these risks. These risks are probably not 100% avoidable, but since they are existential we should be actively working to minimize the chance of them happening, preparing to respond in real time, and preparing to recover afterward if they happen. Covid-19 was a dress rehearsal for dealing with a big global risk event, and humanity mostly failed to prepare or respond effectively. We are lucky it was one we should be able to recover from as long as we get some time before the next body blow. We not only need to prepare for much, much worse events that could happen, we need to match our preparations to the likelihood of more than one of them happening at the same time or in quick succession.

Technological Progress

Enough doom and gloom. We humans are here, alive, and many of us are physically comfortable and have much more leisure time than our ancestors. Our social, economic, and technological systems seem to be muddling through from day to day for the time being. We have intelligence, science, creativity, and problem solving abilities available to us if we choose to make use of them. Let’s see what’s going on with technology.

Biotechnology: The new mRNA technology accelerated by the pandemic opens up potential cures for a range of diseases. We need an effective biological surveillance system akin to nuclear weapons inspections (which we also need) to make sure it is not misused (oops, doom and gloom trying to creep in, but there are some ideas for this.) We have vaccines on the horizon for diseases that have been plaguing us for decades or longer, like malaria and Lyme disease. Malaria kills more children worldwide, year in and year out, than coronavirus has killed per year at its peak.

Promising energy technologies: Space based solar power may finally be getting closer to reality. Ditto for hydrogen fuel cells in vehicles, although not particularly in the U.S. (I’m not sure this is preferable to electric vehicles for everyday transportation, but it seems like a cleaner alternative to diesel and jet fuel when large amounts of power are needed in trucking, construction, and aviation, for example.)

Other technologies: We are actually using technology to catch fish in more sustainable ways, and to grow fish on farms in more sustainable ways. We are getting better at looking for extraterrestrial objects, and the more we look, the more of them we expect to see (this one is exciting and scary at the same time). We are putting satellites in orbit on an unprecedented scale. We have computers, robots, artificial intelligence of a sort, and approaches to use them to potentially accelerate scientific advancements going forward.

The State of Earth’s Ecosystems

The state and trends of the Earth’s ecosystems continue to be concerning. Climate change continues to churn through the public consciousness and our political systems, and painful as the process is I think our civilization is slowly coming to a consensus that something is happening and something needs to be done about it (decades after we should have been able to do this based on the evidence and knowledge available.) When it comes to our ecosystems, however, I think we are in the very early stages of this process. This is something I would like to focus on in this blog in the coming year. My work and family life are busy, and I have decided to take on an additional challenge of becoming a student again for the first time in the 21st century, but somehow I will persevere. If you are reading this shortly after I write it in January 2022, here’s to good luck and prosperity in the new year!

October 2021 in Review

Most frightening and/or depressing story: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.

Most hopeful story: The situation with fish and overfishing is actually much better than I thought.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?

Covid-19 probably wasn’t made in a lab, but something like it could be at any time

This Atlantic article is about a grant proposal to artificially create something very close to Covid-19 in a laboratory. Not to worry, it was not funded and it does not prove or disprove the “lab leak hypothesis”. Wait a minute, regardless of the lab leak hypothesis, what is chilling here is that the technology exists to create a Covid-like bioweapon or something even worse in a laboratory right now. This does not particularly surprise me, but it is scary. Even if we assume scientists in leading countries like the U.S. and China are relatively well regulated and have relatively high ethical standards, somewhere in the world there will be experts who are not as ethical and people willing to fund them. And over time, the technology will become more accessible to more people. And garage biotechnology will be harder to monitor and control than nuclear technology.

If I were spinning conspiracy theories here, I would say isn’t it an interesting coincidence that U.S. laboratories are set up to genetically engineer a Covid-19 if they want to, and U.S. laboratories also happened to have the vaccine for Covid-19 pretty much developed and ready to commercialize when needed. Hmm…I have no evidence of this and am not saying it is likely, I am just saying it is a story that would not be inconsistent with reality.

July 2021 in Review

July 2021 is in the books. In current events (I’m writing on Sunday, August 1), the Delta variant of Covid is now ripping through the unvaccinated population in the U.S. and predictably leaking out into the vaccinated population. I wasn’t too focused on Covid in July though, looking at the posts I have chosen below.

Most frightening and/or depressing story: The western-U.S. megadrought looks like it is settling in for the long haul.

Most hopeful story: A new Lyme disease vaccine may be on the horizon (if you’re a human – if you are a dog, talk to your owner about getting the approved vaccine today.) I admit, I had to stretch a bit to find a positive story this month.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: “Cliodynamics” is an attempt at a structured, evidence-based way to test hypotheses about history.

ARPA-H

ARPA-H is an idea for a new U.S. agency (probably within the existing National Institutes of Health) focused on leading edge medical and biotech research. It seems like a bit of a gimmick to me, but if this is what it takes to fund research and development (as opposed to just funding more research and development) I am all for it. The U.S. should have a competitive advantage here, and this should benefit out citizens.

biotech roundup

Here’s a quick roundup of mind-blowing biotech stories:

  • Genetically modified mosquitoes to be released in Key West. This has been talked about, planned, and argued over for quite awhile. It sounds like it is probably going to happen in real life “this spring”.
  • Remember the doctor/scientist in China who claimed he modified two twin babies’ DNA to make them HIV-resistant? He’s in jail now. One of the twins may actually be HIV-resistant, but the other one has a completely artificial gene never seen before in the human species due to an error. Which may do absolutely nothing and never cause any problems. But these genes may also be inheritable, meaning they could persist through the generations if these children grow up and decide to have their own children. I’m kind of hoping the media leaves these particular children and their future reproductive choices alone though.
  • Scientists have created human-monkey chimera embryos. This is for medical experimentation. There could be benefits, but also profoundly disturbing questions about what kinds of lives these individuals (people?) could have and what their (human?) rights should be.

a new book about longevity research

We should try to be more like the Galapagos tortoises, which achieve a state of “negligible senescence” and stay there for many decades. This is according to a new book called Ageless: The New Science of Getting Older without Getting Old. From the New York Times (which, just as a reminder, I will never subscribe to until/unless they apologize for lying to me about weapons of mass destruction):

This is, in fact, “what we should aim for,” Steele says: “a risk of death, disability, frailty and illness which doesn’t depend on how long ago you were born.” In precise and sometimes dense detail he lays out the means by which science could effectively eliminate human aging. These approaches fall into four categories: “removing bad things that accumulate,” “renewing things which are broken or lost,” “repairing things which are damaged or out of kilter” and “reprogramming our biology to slow or reverse aging.”

New York Times

Overpopulation and funding pensions might become an issue in such a world. Then again, if we are really losing our ability to reproduce through natural means, we might need to become a living dead species just to be able to stick around for awhile.

February 2021 in Review

Most frightening and/or depressing story: For people who just don’t care that much about plants and animals, the elevator pitch on climate change is it is coming for our houses and it is coming for our food and water.

Most hopeful story: It is possible that mRNA technology could cure or prevent herpes, malaria, flu, sickle cell anemia, cancer HIV, Zika and Ebola (and obviously coronavirus). With flu and coronavirus, it may become possible to design a single shot that would protect against thousands of strains. It could also be used for nefarious purposes, and to protect against that are ideas about what a biological threat surveillance system could look like.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: At least one serious scientist is arguing that Oumuamua was only the tip of an iceberg of extraterrestrial objects we should expect to see going forward.

what a global pandemic/bioweapon surveillance regime could look like

It’s pretty clear that the world needs some kind of surveillance or inspection regime to monitor both biological weapons and natural disease outbreaks. This Wired article goes into some of the possibilities.

  • The WHO is an obvious possibility, but requires full cooperation of member states so this limits what it can do, even if it were well funded.
  • Something like the International Atomic Energy Agency is a possibility. It would have to be established by a treaty and would have the ability to swoop in and inspect advanced biological labs (these are called “biosafety level 4” or BSL-4) on short notice.
  • There is an existing treaty called the Biological Weapons Convention which might have the authority to create this body, but the article says it is somewhat ineffective and a new treaty wouldn’t need to have as many parties, just starting with the major players and letting others sign on over time.
  • Another model is the Organization for the Prohibition of Chemical Weapons, which is similar to IAEA.
  • The UN Security Council would also have the authority to establish a new inspection body, kind of like it did for Iraq in the 1990s (which turned out great… and this is the problem, the UN lost a lot of its previous credibility in that debacle.)

The BSL-4 labs are proliferating around the world according to the article, and this seems like a scary situation to me.

My modest proposal would be to fund the WHO fully right away and have it investigate natural disease outbreaks with member state cooperation. Then have the Security Council establish the heavy-duty biological weapons inspection program with the heavies right away. Like it or not, we also need surveillance to find the hidden labs or even just people messing around with dangerous stuff in their garages and basements. This will be much easier for the little guy to do than, say, getting your hands on some enriched uranium or Novachok.

This is an existential risk – we may not get many chances to make mistakes and learn from them. The risk will keep increasing and under any kind of moral or responsible government framework it has to be dealt with right away.

more on mRNA technology for vaccines and beyond

There are several interesting nuggets in this MIT Technology Review article:

  • A lot of the technology was developed by the University of Pennsylvania in Philadelphia (which I have mixed feelings about – it’s essentially a giant evil greedy corporation in most ways, but it does provide a lot of jobs locally – much like any giant inefficient Soviety industry, and obviously it created this technology for greedy purposes which now has the potential to save hundreds of millions of lives while making a few greedy people extraordinarily rich.)
  • The technology essentially gets your body to make its own medicine, “turning a human body into a bioreactor”. However, doesn’t work well (so far) for medicines that need to be taken repeatedly, which is most medicines except vaccines. So vaccines are the most obvious candidate for now. Combining it with gene editing technology holds the promise of permanent protection against disease, even handed down the generations, but there are also some scary risks here.
  • It may work for herpes, malaria, flu, sickle cell anemia, cancer and HIV. For flu and coronavirus, there is a possibility of “universal vaccines” that would protect against thousands of strains with a single shot.
  • The vaccine was designed within 48 hours of the scientists receiving its DNA sequence, and ready for animal trials in less than six weeks. (This is exciting, because it suggests the possibility of responding to new threats quickly in the future, whether natural or manmade.)
  • “vaccine programs for emerging threats like Zika or Ebola, where outbreaks come and go, would deliver a -66% return on average.” (sounds like an obvious, clear textbook market failure to me and an obvious moral requirement for government to step in)
  • The researchers are advocating for the government to create “megafactories” for producing mRNA that could be leased to companies in normal times, but taken over by the government to pump out vaccines quickly in times of crisis. They liken this to how governments “governments spend billions on nuclear weapons they hope to never use”. (They have this one wrong – it’s trillions! And if we need a military reason to do this, we need this to protect against biowarfare and bioterrorism in addition to naturally arising pandemics. It’s an existential threat and like I said, an absolute moral imperative for government to make this happen.)
  • The article also mentions an experimental gene therapy cure for blindness. Exciting but costs about a million dollars right now for two eyes.