Tag Archives: longevity

2021: Year in Review

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As per usual, I’ll list out and link to the stories I chose as the most frightening, most hopeful, and most interesting each month in 2021. Then I’ll see if I have anything smart to say about how it all fits together.

Survey of the Year’s Stories and Themes

Most frightening and/or depressing stories:

  • JANUARY: A China-Taiwan military conflict is a potential start-of-World-War-III scenario. This could happen today, or this year, or never. Let’s hope for the latter. This is a near-term existential risk, but I have to break my own “rule of one” and give honorable mention to two longer-term scary things: crashing sperm counts and the climate change/fascism/genocide nexus.
  • FEBRUARY: For people who just don’t care that much about plants and animals, the elevator pitch on climate change is it is coming for our houses and it is coming for our food and water.
  • MARCH: In the U.S. upper Midwest (I don’t know if this region is better or worse than the country as a whole, or why they picked it), electric blackouts average 92 minutes per year, versus 4 minutes per year in Japan.
  • APRIL: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.
  • MAY: The Colorado River basin is drying out.
  • JUNE: For every 2 people who died of Covid-19 in the U.S. about 1 additional person died of indirect effects, such as our lack of a functioning health care system and safe streets compared to virtually all our peer countries.
  • JULY: The western-U.S. megadrought looks like it is settling in for the long haul.
  • AUGUST: The U.S. is not prepared for megadisasters. Pandemics, just to cite one example. War and climate change tipping points, just to cite two others. Solutions or at least risk mitigation measures exist, such as getting a health care system, joining the worldwide effort to deal with carbon emissions, and as for war, how about just try to avoid it?
  • SEPTEMBER: The most frightening climate change tipping points may not be the ones we hear the most about in the media (at least in my case, I was most aware of melting ice sheets in Greenland and Antarctica, collapse of ocean circulation patterns). The most damaging may be melting permafrost on land and methane hydrates underwater, both of which contain enormous amounts of methane which could set off a catastrophic and unstoppable feedback loop if released in large quantities.
  • OCTOBER: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.
  • NOVEMBER: Freakonomics podcast explained that there is a strong connection between cars and violence in the United States. Because cars kill and injure people on a massive scale, they led to an expansion of police power. Police and ordinary citizens started coming into contact much more often than they had. We have no national ID system so the poor and disadvantaged often have no ID when they get stopped. Everyone has guns and everyone is jumpy. Known solutions (safe street design) and near term solutions (computer-controlled vehicles?) exist, but are we going to pursue them as a society? I guess I am feeling frightened and/or depressed today, hence my choice of category here.
  • DECEMBER: Mass migration driven by climate change-triggered disasters could be the emerging big issue for 2022 and beyond. Geopolitical instability is a likely result, not to mention enormous human suffering.

Most hopeful stories:

  • JANUARY: Computer modeling, done well, can inform decisions better than data analysis alone. An obvious statement? Well, maybe to some but it is disputed every day by others, especially staff at some government regulatory agencies I interact with.
  • FEBRUARY: It is possible that mRNA technology could cure or prevent herpes, malaria, flu, sickle cell anemia, cancer, HIV, Zika and Ebola (and obviously coronavirus). With flu and coronavirus, it may become possible to design a single shot that would protect against thousands of strains. It could also be used for nefarious purposes, and to protect against that are ideas about what a biological threat surveillance system could look like.
  • MARCH: I officially released my infrastructure plan for America, a few weeks before Joe Biden released his. None of the Sunday morning talk shows has called me to discuss so far. Unfortunately, I do not have the resources of the U.S. Treasury or Federal Reserve available to me. Of course, neither does he unless he can convince Congress to go along with at least some portion of his plans. Looking at his proposal, I think he is proposing to direct the fire hoses at the right fires (children, education, research, water, the electric grid and electric vehicles, maintenance of highways and roads, housing, and ecosystems. There is still no real planning involved, because planning needs to be done in between crises and it never is. Still, I think it is a good proposal that will pay off economically while helping real people, and I hope a substantial portion of it survives.
  • APRIL: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.
  • MAY: An effective vaccine for malaria may be on the way. Malaria kills more children in Africa every year than Covid-19 killed people of all ages in Africa during the worst year of the pandemic. And malaria has been killing children every year for centuries and will continue long after Covid-19 is gone unless something is done.
  • JUNE: Masks, ventilation, and filtration work pretty well to prevent Covid transmission in schools. We should learn something from this and start designing much healthier schools and offices going forward. Design good ventilation and filtration into all buildings with lots of people in them. We will be healthier all the time and readier for the next pandemic. Then masks can be slapped on as a last layer of defense. Enough with the plexiglass, it’s just stupid and it’s time for it to go.
  • JULY: A new Lyme disease vaccine may be on the horizon (if you’re a human – if you are a dog, talk to your owner about getting the approved vaccine today.) I admit, I had to stretch a bit to find a positive story this month.
  • AUGUST: The Nordic welfare model works by providing excellent benefits to the middle class, which builds the public and political support to collect sufficient taxes to provide the benefits, and so on in a virtuous cycle. This is not a hopeful story for the U.S., where wealthy and powerful interests easily break the cycle with anti-tax propaganda, which ensure benefits are underfunded, inadequate, available only to the poor, and resented by middle class tax payers.
  • SEPTEMBER: Space-based solar power could finally be in our realistic near-term future. I would probably put this in the “interesting” rather than “hopeful” category most months, but I really struggled to come up with a hopeful story this month. I am at least a tiny bit hopeful this could be the “killer app” that gets humanity over the “dirty and scarce” energy hump once and for all, and lets us move on to the next layer of problems.
  • OCTOBER: The situation with fish and overfishing is actually much better than I thought.
  • NOVEMBER: Urban areas may have some ecological value after all.
  • DECEMBER: Covid-19 seems to be “disappearing” in Japan, or at least was before the Omicron wave. Maybe lessons could be learned. It seems possible that East Asian people have at least some genetic defenses over what other ethnic groups have, but I would put my money on tight border screening and an excellent public health care system. Okay, now I’m starting to feel a bit depressed again, sitting here in the U.S. where we can’t have these nice things thanks to our ignorant politicians.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

  • JANUARY: There have been fabulous advances in note taking techniques! Well, not really, but there are some time honored techniques out there that could be new and beneficial for many people to learn, and I think this is an underappreciated productivity and innovation skill that could benefit people in a lot of areas, not just students.
  • FEBRUARY: At least one serious scientist is arguing that Oumuamua was only the tip of an iceberg of extraterrestrial objects we should expect to see going forward.
  • MARCH: One study says 1-2 days per week is a sweet spot for working from home in terms of a positive economic contribution at the national scale. I think it is about right psychologically for many people too. However, this was a very theoretical simulation, and other studies attempting to measure this at the individual or firm scale have come up with a 20-50% loss in productivity. I think the jury is still out on this one, but I know from personal experience that people need to interact and communicate regularly for teams to be productive, and some people require more supervision than others, and I don’t think technology is a perfect substitute for doing these things in person so far.
  • APRIL: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.
  • MAY: I learned about Lawrence Kohlberg, who had some ideas on the use of moral dilemmas in education.
  • JUNE: The big U.S. government UFO report was a dud. But what’s interesting about it is that we have all quietly seemed to have accepted that something is going on, even if we have no idea what it is, and this is new.
  • JULY: “Cliodynamics” is an attempt at a structured, evidence-based way to test hypotheses about history.
  • AUGUST: Ectogenesis is an idea for colonizing other planets that involves freezing embryos and putting them on a spaceship along with robots to thaw them out and raise them. Fungi could also be very useful in space, providing food, medicine, and building materials.
  • SEPTEMBER: Philip K. Dick was not only a prolific science fiction author, he also developed a comprehensive theory of religion which could possibly even be the right one. Also, possibly related but not really, if there are aliens out there they might live in creepy colonies or super-organisms like ants or termites.
  • OCTOBER: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?
  • NOVEMBER: Peter Turchin continues his project to empirically test history. In this article, he says the evidence points to innovation in military technologies being driven by “world population size, connectivity between geographical areas of innovation and adoption, and critical enabling technological advances, such as iron metallurgy and horse riding“. What does not drive innovation? “state-level factors such as polity population, territorial size, or governance sophistication“. As far as the technologies coming down the pike in 2022, one “horizon scan” has identified “satellite megaconstellations, deep sea mining, floating photovoltaics, long-distance wireless energy, and ammonia as a fuel source”.
  • DECEMBER: Time reminded us of all the industries Elon Musk has disrupted so far: human-controlled, internal-combustion-fueled automobiles; spaceflight; infrastructure construction (I don’t know that he has really achieved any paradigm shifts here, but not for lack of trying), “artificial intelligence, neurotechnology, payment systems and cryptocurrency.” I’m not sure I follow a couple of these, but I think they missed satellites.

Continuing Signs of U.S. Relative Decline

Signs of U.S. decline relative to our peer group of advanced nations are all around us. I don’t know that we are in absolute decline, but I think we are now below average among the most advanced countries in the world. We are not investing in the infrastructure needed in a modern economy just to reduce friction and let the economy function. The annual length of electric blackouts in the U.S. (hours) compared to leading peers like Japan (minutes) is just one telling indicator. In March, I looked at the Build Back Better proposal and concluded that it was more like directing a firehose of money at a range of problems than an actual plan, but I hoped at least some of it would happen. My rather low but not zero expectations were met, as some limited funding was provided for “hard infrastructure” and energy/emissions projects, but little or nothing (so far, as I write this) to address our systemic failures in health care, child care, or education. The crazy violence on our streets, both gun-related and motor vehicle-related, is another indicator. Known solutions to all these problems exist and are being implemented to various extents by peer countries. Meanwhile our toxic politics and general ignorance continue to hold us back. Biden really gave it his best shot – but if this is our “once in a generation” attempt, we are headed down a road where we will no longer qualify as a member of the pack of elite countries, let alone its leader.

The Climate Change, Drought, Food, Natural Disaster, Migration and Geopolitical Instability Nexus

2021 was a pretty bad year for storms, fires, floods, and droughts. All these things affect our homes, our infrastructure, our food supply, and our water supply. Drought in particular can trigger mass migration. Mass migration can be a disaster for human rights and human dignity in and of itself, and managing it effectively is difficult even for well-intentioned governments. But an insidious related problem is that migration pressure can tend to fuel right wing populist and racist political movements. We see this happening all over the world, and the situation seems likely to get worse.

Tipping Points and other Really Bad Things We Aren’t Prepared For

We can be thankful that nothing really big and new and bad happened in 2021. My apologies to anyone reading this who lost someone or had a tough year. Of course, plenty of bad things happened to good people, and plenty of bad things happened on a regional or local scale. But while Covid-19 ground on and plenty of local and regional-scale natural disasters and conflicts occurred, there were no new planetary-scale disasters. This is good because humanity has had enough trouble dealing with Covid-19, and another major disaster hitting at the same time could be the one that brings our civilization to the breaking point.

So we have a trend of food insecurity and migration pressure creeping up on us over time, and we are not handling it well even given time to do so. Maybe we can hope that some adjustments will be made there to get the world on a sustainable track. Even if we do that, there are some really bad things that could happen suddenly. Catastrophic war is an obvious one. A truly catastrophic pandemic is another (as opposed to the moderately disastrous pandemic we have just gone through.) Creeping loss of human fertility is one that is not getting much attention, but this seems like an existential risk if it were to cross some threshold where suddenly the global population starts to drop quickly and we can’t do anything about it. Asteroids were one thing I really thought we didn’t have to worry much about on the time scale of any human alive today, but I may have been wrong about that. And finally, the most horrifying risk to me in the list above is the idea of an accelerating, runaway feedback loop of methane release from thawing permafrost or underwater methane hydrates.

We are almost certainly not managing these risks. These risks are probably not 100% avoidable, but since they are existential we should be actively working to minimize the chance of them happening, preparing to respond in real time, and preparing to recover afterward if they happen. Covid-19 was a dress rehearsal for dealing with a big global risk event, and humanity mostly failed to prepare or respond effectively. We are lucky it was one we should be able to recover from as long as we get some time before the next body blow. We not only need to prepare for much, much worse events that could happen, we need to match our preparations to the likelihood of more than one of them happening at the same time or in quick succession.

Technological Progress

Enough doom and gloom. We humans are here, alive, and many of us are physically comfortable and have much more leisure time than our ancestors. Our social, economic, and technological systems seem to be muddling through from day to day for the time being. We have intelligence, science, creativity, and problem solving abilities available to us if we choose to make use of them. Let’s see what’s going on with technology.

Biotechnology: The new mRNA technology accelerated by the pandemic opens up potential cures for a range of diseases. We need an effective biological surveillance system akin to nuclear weapons inspections (which we also need) to make sure it is not misused (oops, doom and gloom trying to creep in, but there are some ideas for this.) We have vaccines on the horizon for diseases that have been plaguing us for decades or longer, like malaria and Lyme disease. Malaria kills more children worldwide, year in and year out, than coronavirus has killed per year at its peak.

Promising energy technologies: Space based solar power may finally be getting closer to reality. Ditto for hydrogen fuel cells in vehicles, although not particularly in the U.S. (I’m not sure this is preferable to electric vehicles for everyday transportation, but it seems like a cleaner alternative to diesel and jet fuel when large amounts of power are needed in trucking, construction, and aviation, for example.)

Other technologies: We are actually using technology to catch fish in more sustainable ways, and to grow fish on farms in more sustainable ways. We are getting better at looking for extraterrestrial objects, and the more we look, the more of them we expect to see (this one is exciting and scary at the same time). We are putting satellites in orbit on an unprecedented scale. We have computers, robots, artificial intelligence of a sort, and approaches to use them to potentially accelerate scientific advancements going forward.

The State of Earth’s Ecosystems

The state and trends of the Earth’s ecosystems continue to be concerning. Climate change continues to churn through the public consciousness and our political systems, and painful as the process is I think our civilization is slowly coming to a consensus that something is happening and something needs to be done about it (decades after we should have been able to do this based on the evidence and knowledge available.) When it comes to our ecosystems, however, I think we are in the very early stages of this process. This is something I would like to focus on in this blog in the coming year. My work and family life are busy, and I have decided to take on an additional challenge of becoming a student again for the first time in the 21st century, but somehow I will persevere. If you are reading this shortly after I write it in January 2022, here’s to good luck and prosperity in the new year!

April 2021 in Review

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Most frightening and/or depressing story: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.

Most hopeful story: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.

a new book about longevity research

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We should try to be more like the Galapagos tortoises, which achieve a state of “negligible senescence” and stay there for many decades. This is according to a new book called Ageless: The New Science of Getting Older without Getting Old. From the New York Times (which, just as a reminder, I will never subscribe to until/unless they apologize for lying to me about weapons of mass destruction):

This is, in fact, “what we should aim for,” Steele says: “a risk of death, disability, frailty and illness which doesn’t depend on how long ago you were born.” In precise and sometimes dense detail he lays out the means by which science could effectively eliminate human aging. These approaches fall into four categories: “removing bad things that accumulate,” “renewing things which are broken or lost,” “repairing things which are damaged or out of kilter” and “reprogramming our biology to slow or reverse aging.”

New York Times

Overpopulation and funding pensions might become an issue in such a world. Then again, if we are really losing our ability to reproduce through natural means, we might need to become a living dead species just to be able to stick around for awhile.

the “best” health advice from 2019

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The Week has cherry picked a few studies from 2019 as best. Although they did pick ones with large sample sizes, what would be “best” to me would be some kind of meta-analysis of all studies published and what they said on balance, with some kind of grading for quality and communication of the uncertainty involved. That would be awesome journalism, but I imagine it would be expensive. The great news is that if you add up all the percentages that doing this and that can reduce your chances of death, you can live forever! Anyway, here is my quick summary:

  • Exercise, fruits, vegetables, and whole grains just never go out of style. More whole foods (the thing, not the chain) and less processed foods in general seem to be a very good idea. Seriously, just orient your life style around these things and it is very unlikely the scientific consensus will change some day and tell you it was a bad idea.
  • Napping is good for you – this particular study says “five minutes to an hour once or twice a week”. I’m not surprised that rest is good for the heart, but I thought there was an emerging consensus that maintaining a consistent schedule on all days was good, and this seems to contradict that a bit.
  • Parents are stressed out while kids are young, then ultimately glad they had the kids later in life. This doesn’t surprise me since I am living through the stressed out part, but I do find it helpful to put myself in my future self’s shoes and ask if I would regret having children. In fact, my wife and I did that when we made the decision to have children, and the answer was and is no, we have no regrets. The distinction between happiness in the moment and overall life satisfaction also comes to mind.
  • Aspirin and ibuprofen seem to help your heart, but also raise your risk of internal bleeding. It’s probably best not to self-medicate.
  • Smoking and getting hit on the head, even gently, are not good for you.

June 2019 in Review

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Most frightening and/or depressing story:

  • The world economy appears to be slowing, even though U.S. GDP is growing as the result of the post-2007 recovery finally taking hold, juiced by a heavy dose of pro-cyclical government spending. The worry is that if and when there is eventually a shock to the system, there will be little room for either fiscal or monetary policy to respond. Personally, the partisan in me is thinking any time before November 2020 is as good a time for any for a recession to hit the U.S. I am a couple decades from retirement, and picturing that bumper sticker “Lord, Just Give Me One More Bubble”. Of course, this is selfish thinking when there are many people close to retirement and many families struggling to get by out there. And short-term GDP growth is not the only metric. The U.S. is falling behind its developed peers on a wide range of metrics that matter to people lives, including infrastructure, health care costs and outcomes, life expectancy, maternal and infant mortality, addiction, suicide, poverty, and hunger. And it’s not just that we are no longer in the lead on these metrics, we are below average and falling. Which is why I am leading the charge to Make America Average Again!

Most hopeful story:

  • There have been a number of serious proposals and plans for disarmament and world peace in the past, even since World War II. We have just forgotten about them or never heard of them.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both:

  • In technology news, Elon Musk is planning to launch thousands of satellites. And I learned a new acronym, DARQ: “distributed ledger technology (DLT), artificial intelligence (AI), extended reality (XR) and quantum computing”. And in urban planning news, I am sick and tired of the Dutch just doing everything right.

 

what’s new with longevity treatments

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This article in The Week mentions a few things.

Humans grow fewer blood vessels in their muscles with age, which is believed to result in the gradual breakdown of vital organs. The same pattern exists in mice. In 2018, Harvard researchers fed mice a chemical to manipulate the gene associated with blood vessel growth and found that old mice subsequently were able to run on a treadmill 56 percent longer. While that work continues, biohackers are transfixed by nootropics — “smart drugs,” amino acids, and other supplements that purportedly boost cognitive abilities and prevent brain aging.

Mainstream scientists and doctors are still saying nay. I don’t know but exercising to keep the oxygen level up seems like a good idea.

2018 in Review

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Most frightening and/or depressing stories:

  • JANUARY: Cape Town, South Africa looked to be in imminent danger of running out of water. They got lucky, but the question is whether this was a case of serious mismanagement or an early warning sign of water supply risk due to climate change. Probably a case of serious mismanagement of the water supply while ignoring the added risk due to climate change. Longer term, there are serious concerns about snowpack-dependent water supplies serving large urban populations in Asia and western North America.
  • FEBRUARY: Cape Town will probably not be the last major city to run out of water. The other cities at risk mentioned in this article include Sao Paulo, Bangalore, Beijing, Cairo, Jakarta, Moscow, Istanbul, Mexico City, London, Tokyo, and Miami.
  • MARCH: One reason propaganda works is that even knowledgeable people are more likely to believe a statement the more often it is repeated.
  • APRIL: That big California earthquake is still coming.
  • MAY: The idea of a soft landing where absolute dematerialization of the economy reduces our ecological footprint and sidesteps the consequences of climate change through innovation without serious pain may be wishful thinking.
  • JUNE: The Trump administration is proposing to subsidize coal-burning power plants. Meanwhile the long-term economic damage expected from climate change appears to be substantial. For one thing, Hurricanes are slowing down, which  means they can do more damage in any one place. The rate of melting in Antarctic ice sheets is accelerating.
  • JULY: The UN is warning as many as 10 million people in Yemen could face starvation by the end of 2018 due to the military action by Saudi Arabia and the U.S. The U.S. military is involved in combat in at least 8 African countries. And Trump apparently wants to invade Venezuela.
  • AUGUST: Noam Chomsky doesn’t love Trump, but points out that climate change and/or nuclear weapons are still existential threats and that more mainstream leaders and media outlets have failed just as miserably to address them as Trump has. In related news, the climate may be headed for a catastrophic tipping point and while attention is mostly elsewhere, a fundamentalist takeover of Pakistan’s nuclear arsenal is still one of the more serious risks out there.
  • SEPTEMBER: A huge earthquake in the Pacific Northwest could be by far the worst natural disaster ever seen.
  • OCTOBER: The Trump administration has slashed funding to help the U.S. prepare for the next pandemic.
  • NOVEMBER: About half a million people have been killed in Iraq, Afghanistan, and Pakistan since the U.S. invasions starting in 2001. This includes only people killed directly by violence, not disease, hunger, thirst, etc.
  • DECEMBER: Climate change is just bad, and the experts seem to keep revising their estimates from bad to worse. The Fourth National Climate Assessment produced by the U.S. government is not an uplifting publication. In addition to the impacts of droughts, storms, and fires, it casts some doubt on the long-term security of the food supply. An article in Nature was also not uplifting, arguing that climate change is happening faster than expected due to a combination of manmade and natural trends.

Climate change, nuclear weapons, and pandemics. If I go back and look at last year’s post, this list of existential threats is going to be pretty much the same. Add to this the depressing grind of permanent war which magnifies these risks and diverts resources that could be used to deal with them. True, we could say that we got through 2018 without a nuclear detonation, pandemic, or ecological collapse, and under the circumstances we should sit back, count our blessings, and wait for better leadership. And while our leadership is particularly inept at the moment, I think Noam Chomsky has a point that political administration after political administration has failed to solve these problems and this seems unlikely to improve. The earthquake risk is particularly troublesome. Think about the shock we felt over the inept response to Katrina, and now think about how essentially the same thing happened in Puerto Rico, we are not really dealing with it in an acceptable way, and the public and news media have essentially just shrugged it off and moved on. If the hurricanes, floods, fires and droughts just keep hitting harder and more often, and we don’t fully respond to one before the next hits, it could mean a slow downward spiral. And if that means we gradually lose our ability to bounce back fully from small and medium size disasters, a truly huge disaster like an epic earthquake on the west coast might be the one that pushes our society to a breaking point.

Most hopeful stories:

I believe our children are our future…ya ya blahda blahda. It’s a huge cliche, and yet to be hopeful about our world I have to have some hope that future generations can be better system thinkers and problem solvers and ethical actors than recent generations have been. Because despite identifying problems and even potential solutions we are consistently failing to make choices as a society that could divert us from the current failure path. And so I highlighted a few stories above about ideas for better preparing future generations, ranging from traditional school subjects like reading and music, to more innovative ones like meditation and general system theory, and just maybe we should be open to the idea that the right amount of the right drugs can help.

Fossil fuels just might be on their way out, as alternatives start to become economical and public outrage slowly, almost imperceptibly continues to build.

There is real progress in the fight against disease, which alleviates enormous quantities of human suffering. I mention AIDS, diabetes, and Alzheimer’s disease above. We can be happy about that, of course. There are ideas about how to grow more food, which is going to be necessary to avoid enormous quantities of human suffering. Lest anyone think otherwise, my position is that we desperately need to reduce our ecological footprint, but human life is precious and nobody deserves to suffer illness or hunger.

Good street design that lets people get around using mostly their own muscle power. It might not be sexy, but it is one of the keys to physical and mental health, clean air and water, biodiversity, social and economic vibrancy in our cities. Come to think of it, I take that back, it can be sexy if done well.

Good street design and general systems theory – proof that solutions exist and we just don’t recognize or make use of them. Here’s where I want to insert a positive sentence about how 2019 is the year this all changes for the better. Well, sorry, you’ll have to find someone less cynical than me, and/or with much better powers of communication and persuasion than me to get the ball rolling. On the off chance I have persuaded you, and you have communication and/or persuasion super powers, let me know.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

Whatever else happens, technology and accumulation of human knowledge in general march on, of course. Computer, robotics, and surveillence technology march on. The human move into space is much slower and painful than many would have predicted half a century ago, and yet it is proceeding.

I’ll never drop the waterless sanitation thing, no matter how much others make fun of me. It’s going to happen, eventually. I don’t know whether we will colonize Mars or stop defecating in our water supply first, but both will happen.

The gene drive thing is really wild the more I think about it. This means we now have the ability to identify a species or group of species we don’t want to exist, then cause it not to exist in relatively short order. This seems like it could be terrifying in the wrong hands, doesn’t it? I’m not even sure I buy into the idea that rats and mosquitoes have no positive ecological functions at all. Aren’t there bats and birds that rely on mosquitoes as a food source? Okay, I’m really not sure what redeeming features rats have, although I did read a few years ago that in a serious food crunch farming rats would be a much more efficient way of turning very marginal materials into edible protein than chicken.

The universe in a bottle thing is mind blowing if you spend too much time thinking about it. It could just be bottles all the way down. It’s best not to spend too much time thinking about it.

That’s it, Happy 2019!

ultrasound treatment for dementia

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This article in New Atlas (which I don’t know anything about) reports on an ultrasound-based treatment for dementia and Alzheimer’s that has been successful in mice and is moving to human trials next year.

The ultrasound treatment was first developed back in 2015 at the University of Queensland. The initial research was working to find a way to use ultrasound to temporarily open the blood-brain barrier with the goal of helping dementia-battling antibodies better reach their target in the brain. However, early experiments with mice surprisingly revealed the targeted ultrasound waves worked to clear toxic amyloid protein plaques from the brain without any additional therapeutic drugs.

“The ultrasound waves oscillate tremendously quickly, activating microglial cells that digest and remove the amyloid plaques that destroy brain synapses,” explained Jürgen Götz, one of the researchers on the project back in 2015. “The word ‘breakthrough’ is often mis-used, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach.”

23 is not enough for me

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This article in Wired explains how there is a lot more to sequencing the whole genome than just 23 genes. The cost of full sequencing has dropped to $1000, which is considered an enormous breakthrough, and it is expected to continue to fall. One company is even offering a $200 black Friday special even though they admit it is a loss leader.

Today, slightly more than a million people have had their whole genomes sequenced. Compare that to the 17 million estimated to have had their DNA analyzed with direct-to-consumer tests sold by 23andMe and Ancestry. They use a technology called genotyping, which takes about a million snapshots of a person’s genome. That might sound like a lot, but it’s really less than 1 percent of the full picture. Genotyping targets short strings of DNA that scientists already know have a strong association with a given trait. So say, for example, scientists discover a new gene that increases your risk of developing brain cancer. If that gene is not one that 23andMe looks at (because how would it know to look if the gene hasn’t been discovered yet), then you’d have to get tested all over again to learn more about your brain cancer risk. Whole genome data on the other hand, once you have it, can be queried with computer algorithms whenever a new genetic discovery gets made.

Here’s a good example of just how much more info is in a whole genome: Earlier this year, 23andMe got FDA approval to give consumers information about their BRCA1 and BRCA2 genes. More than 1,000 mutations in these genes are known to increase women’s chances of breast and ovarian cancers by as much as 75 and 50 percent, respectively. 23andMe’s test picks up the three BRCA mutations most commonly found in individuals of Ashkenazi Jewish descent, and geneticists have voiced concern that the results could leave people with a false sense of security. Veritas’ tests, on the other hand, scan for all of them and, according to the company, turn up five to seven variants of varying concern in those two genes for the average customer.

“organic” eating may lower cancer risk after all

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I haven’t always been on the “organic” band wagon 100%. For one thing, the name is stupid. Chugging a glass of diesel fuel would be about as organic as you could get, in terms of the definition of the word I learned in high school chemistry. I am strongly in favor of sustainable farming practices that build soil, protect biodiversity, and prevent groundwater and surface water pollution. But in terms of health benefits, I have never felt the benefits were all that proven, and to some extent the industry is just based on scare tactics. I also wonder if the billions of humans on the planet can be fed without resorting to fossil fuel-derived fertilizer, and I still think that is dubious. But here is one large study in JAMA that did find significant evidence of a link between organic food (as labeled at the grocery store) and reduced cancer risk.

Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study

Main Outcomes and Measures This study estimated the risk of cancer in association with the organic food score (modeled as quartiles) using Cox proportional hazards regression models adjusted for potential cancer risk factors.

Results Among 68 946 participants (78.0% female; mean [SD] age at baseline, 44.2 [14.5] years), 1340 first incident cancer cases were identified during follow-up, with the most prevalent being 459 breast cancers, 180 prostate cancers, 135 skin cancers, 99 colorectal cancers, 47 non-Hodgkin lymphomas, and 15 other lymphomas. High organic food scores were inversely associated with the overall risk of cancer (hazard ratio for quartile 4 vs quartile 1, 0.75; 95% CI, 0.63-0.88; P for trend = .001; absolute risk reduction, 0.6%; hazard ratio for a 5-point increase, 0.92; 95% CI, 0.88-0.96).

Conclusions and Relevance A higher frequency of organic food consumption was associated with a reduced risk of cancer. Although the study findings need to be confirmed, promoting organic food consumption in the general population could be a promising preventive strategy against cancer.

I researched the risk measures a little. The hazard risk ratio of 0.75 means that people eating mostly organic food (scoring in the top 25% of however they are measuring that) are 25% less likely than people eating the least organic food. That seems significant. From a quick skim, it appears they did try to control for differences in lifestyle (i.e., similar nutrition and exercise levels) and family history of cancer when coming to their conclusions.