Tag Archives: biotechnology

Pfizer and “gain of function” research

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This Pfizer press release just confirms that the technology to make genetically engineered viruses is widespread:

we have conducted research where the original SARS-CoV-2 virus has been used to express the spike protein from new variants of concern. This work is undertaken once a new variant of concern has been identified by public health authorities. This research provides a way for us to rapidly assess the ability of an existing vaccine to induce antibodies that neutralize a newly identified variant of concern…

In a limited number of cases when a full virus does not contain any known gain of function mutations, such virus may be engineered to enable the assessment of antiviral activity in cells. In addition, in vitro resistance selection experiments are undertaken in cells incubated with SARS-CoV-2 and nirmatrelvir in our secure Biosafety level 3 (BSL3) laboratory to assess whether the main protease can mutate to yield resistant strains of the virus.  It is important to note that these studies are required by U.S. and global regulators for all antiviral products and are carried out by many companies and academic institutions in the U.S. and around the world.

Pfizer

So they aren’t creating genetically engineered bioweapons of mass destruction, but they could if they wanted to. Somebody somewhere probably is. Not the U.S. government, which has no track record of lying or trying to dominate the world, and doesn’t collude with big business entities with the technology to do so.

2022 – a “breakthrough year” for transplanting genetically modified pig organs into people

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Yes, the headline pretty much describes what this Wired article is about. The following things have happened:

  • Pig hearts were genetically modified to reduce their odds of being rejected by human recipients.
  • A genetically engineered pig heart was transplanted into a human being, who lived for 60 days. This was considered a success.
  • Genetically modified pig kidneys were transplanted into a brain-dead person and the body was kept alive(?)/functioning for 77 hours.
  • Genetically engineered pig hearts were transplanted into two “recently deceased” human bodies and kept beating for three days.
  • It’s not clear from the article exactly when this happened, but a genetically modified pig heart was transplanted into a baboon and the baboon lived for over two years.

There are some obvious ethical questions here. The living human beings who took part in these studies were close to death and had no other viable options that would extend their lives, and I would assume that both they and the “recently deceased” individuals consented to the tests. And there are people dying every day because their organs fail before they get to the top of the transplant lists. I suppose I would let them use my recently deceased body in this way if it would help someone else. It seems a bit creepy, but to surgeons a human body is just a machine and they are mechanics. And after they shut down my pig heart or whatever, they could still use my body as a crash dummy. Or could they use dead bodies with functioning organs as crash dummies? There’s a disturbing thought, but if it would save the lives of people with actual brains and loved ones it would not be obviously unethical.

Now if we were writing a science fiction horror story, we could probably think of other places to go with this. Paul Macauley’s 1998 story collection The Invisible Country comes to mind. These are mind-blowing, disturbing stories about mistreatment of genetically engineered baboon-human hybrids who are kept as slaves, prostitutes, and worse. Using a deceased human body with no functioning brain for these purposes would be very creepy but less obviously unethical.

Trends in Ecology and Evolution horizon scan

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This journal does an annual “horizon scan” of of emerging topics and issues. Here are a few that caught my eye:

  • “bio-batteries” – “DNA-enabled biobattery technology uses a set of enzymes coupled to DNA to degrade organic compounds, releasing electrons and generating electricity…Such batteries could theoretically supply power densities in orders of magnitude greater than widely used lithium-ion batteries”. There are also new processes for extracting lithium more sustainably from waste materials. So there is some hope that the resource and waste limitations to scaling up renewable energy can be solved. Thermophotovoltaic cells are a third energy storage technology mentioned.
  • more practical methods of converting human urine to fertilizer – This might not sound like a big deal, but our coastal waters are being choked by nutrients both from treated wastewater and from farm runoff, while the nutrients in the farm runoff are derived from fossil fuels in the case of nitrogen or a mined from finite geological resources in the case of phosphate. Reprocessing urine into fertilizer is almost a no-brainer. And the technology has been known for awhile. The problem has been waste taboos which seem to be extremely ingrained in our psyches. I really want this one to be overcome, but as a wastewater industry insider I have become more cynical about this one over time. Genetic engineering of crops to help them take up nitrogen directly from the atmosphere (which peas and beans can do naturally, but most crops can’t) is also mentioned.
  • A particular pathogen that infects amphibians may be spreading to new areas.
  • European countries are considering new policy/legal frameworks for biodiversity reporting and conservation. This might sound boring, but we have gotten there with conventional pollution and we are getting there with greenhouse gases and renewable energy, while land use and conversation have mostly been left out to date.
  • Artificial intelligence is increasingly being used to try to accelerate drug, chemical, and pesticide research.
  • trash reefs – New ecosystems may actually develop and adapt around ocean garbage patches.

human brain cells in rats

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You wouldn’t necessarily get the idea from this Nature article that it is about implanting human brain cells in rats. But according to this (sensationalized?) article in Axios, that is exactly what it is about. The scientists are doing this to study diseases like autism that they can’t just study by growing human brain cells in a jar (which they have been doing for some time, apparently!).

Given all that, this is the paragraph that really caught my eye:

A current concern, though, is whether organoids might be transplanted to non-human primates. Paşca says there is no need: “It’s not something that we would do or that I would encourage doing.”

Axios

So it could be done then. And what can be done, Somebody somewhere will probably eventually do.

I have a childhood memory of seeing the Rats of Nimh on the big screen and being utterly terrified. By the Rats. Who were supposed to be the good guys in the story.

lobsters are not immortal, or at least only sort of

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From McGill University:

So why do we stop growing, while lobsters don’t? The cells that make up our body are constantly making new cells by dividing. A biological technicality causes us to lose a bit of DNA at the ends of our chromosomes (structures made up of DNA and proteins) after each replication. DNA contains the blueprint for our lives, so in order to make sure we aren’t losing crucial information during these divisions, the long molecules of DNA are protected by shorter segments of DNA at their ends called “telomeres.” An analogy would be the plastic tips on a shoelace that prevent it from unraveling. When a cell multiplies, the only part of the chromosome that is lost is a piece of the telomeres. But as we age, our telomeres get shorter, until they reach a critical point where the cell can no longer replicate without damage to its essential DNA. When this occurs, the cell becomes inactive or dies. Shortening of telomeres is linked to senescence and increased risk of disease. Other contributors to aging include oxidative stress (hence the appeal of antioxidants).

Lobsters have a perpetual supply of telomerase – the enzyme that can restore telomeres, helping cells avoid that fateful end. Humans also have telomerase, just not enough to overcome the constant shortening of telomeres. In fact, telomerase is often found in cancer cells, giving tumours a survival advantage.

Unfortunately for our pal Larry, a large supply of telomerase can be a double-edged sword. Lobsters are still more likely to die with age because their hard-shell exoskeleton moults and has to be regrown. This requires reams of energy, eventually too much. As a result, common causes of death for lobsters are exhaustion, immobility, and shell disease, although the leading cause is still predation.

McGill

The article goes on to say that there are actually some jellyfish that are biologically immortal, meaning they do not age or ever die of old age, although they can be killed.

Given an infinite span of time, the odds of a “biologically immortal” organism being killed would seem to be 100%. So this does not sound like immortality to me in a colloquial sense, But figure out this mystery and come up with a drug to restore our telomeres without causing cancer, and we could live for a long, long time if we are careful. Would our brains hold up more than a century or so?

Interestingly, and this is a frequent point of conversation my son likes to bring up, the Norse gods are “biologically immortal” because they do not age but they can be killed (sorry, Thor fans). But the Greek/Roman gods are truly indestructible. I recall one story where Zeus was cut up into little pieces and put into a bag by another one of the gods. Eventually, somebody let him out and the pieces just assembled themselves together again and he continued being Zeus.

May 2022 in Review

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Most frightening and/or depressing story: The lab leak hypothesis is back, baby! Whether Covid-19 was or was not a lab accident, the technology for accidental or intentional release of engineered plagues has clearly arrived. And also, the world is waking up to a serious food crisis.

Most hopeful story: I came up with (but I am sure I didn’t think of it first) the idea of a 21st century bill of rights. This seems to me like a political big idea somebody could run with. I’ll expand on it at some point, but quick ideas would be to clarify that the right to completely free political speech applies to human beings only and put some bounds on what it means for corporations and other legal entities, and update the 18th century idea of “unlawful search and seizure” to address the privacy/security tradeoffs of our modern world. And there’s that weird “right to bear arms” thing. Instead of arguing about what those words meant in the 18th century, we could figure out what we want them to mean now and then say it clearly. For example, we might decide that people have a right to be free of violence and protected from violence, in return for giving up any right to perpetrate violence. We could figure out if we think people have a right to a minimum standard of living, or housing, or health care, or education. And maybe clean up the voting mess?

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: I found one easily accessible and understandable source of Covid-19 wastewater surveillance data.

2021: Year in Review

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As per usual, I’ll list out and link to the stories I chose as the most frightening, most hopeful, and most interesting each month in 2021. Then I’ll see if I have anything smart to say about how it all fits together.

Survey of the Year’s Stories and Themes

Most frightening and/or depressing stories:

  • JANUARY: A China-Taiwan military conflict is a potential start-of-World-War-III scenario. This could happen today, or this year, or never. Let’s hope for the latter. This is a near-term existential risk, but I have to break my own “rule of one” and give honorable mention to two longer-term scary things: crashing sperm counts and the climate change/fascism/genocide nexus.
  • FEBRUARY: For people who just don’t care that much about plants and animals, the elevator pitch on climate change is it is coming for our houses and it is coming for our food and water.
  • MARCH: In the U.S. upper Midwest (I don’t know if this region is better or worse than the country as a whole, or why they picked it), electric blackouts average 92 minutes per year, versus 4 minutes per year in Japan.
  • APRIL: One of the National Intelligence Council’s scenarios for 2040 involves “far-reaching changes designed to address climate change, resource depletion, and poverty following a global food catastrophe caused by climate events and environmental degradation”.
  • MAY: The Colorado River basin is drying out.
  • JUNE: For every 2 people who died of Covid-19 in the U.S. about 1 additional person died of indirect effects, such as our lack of a functioning health care system and safe streets compared to virtually all our peer countries.
  • JULY: The western-U.S. megadrought looks like it is settling in for the long haul.
  • AUGUST: The U.S. is not prepared for megadisasters. Pandemics, just to cite one example. War and climate change tipping points, just to cite two others. Solutions or at least risk mitigation measures exist, such as getting a health care system, joining the worldwide effort to deal with carbon emissions, and as for war, how about just try to avoid it?
  • SEPTEMBER: The most frightening climate change tipping points may not be the ones we hear the most about in the media (at least in my case, I was most aware of melting ice sheets in Greenland and Antarctica, collapse of ocean circulation patterns). The most damaging may be melting permafrost on land and methane hydrates underwater, both of which contain enormous amounts of methane which could set off a catastrophic and unstoppable feedback loop if released in large quantities.
  • OCTOBER: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.
  • NOVEMBER: Freakonomics podcast explained that there is a strong connection between cars and violence in the United States. Because cars kill and injure people on a massive scale, they led to an expansion of police power. Police and ordinary citizens started coming into contact much more often than they had. We have no national ID system so the poor and disadvantaged often have no ID when they get stopped. Everyone has guns and everyone is jumpy. Known solutions (safe street design) and near term solutions (computer-controlled vehicles?) exist, but are we going to pursue them as a society? I guess I am feeling frightened and/or depressed today, hence my choice of category here.
  • DECEMBER: Mass migration driven by climate change-triggered disasters could be the emerging big issue for 2022 and beyond. Geopolitical instability is a likely result, not to mention enormous human suffering.

Most hopeful stories:

  • JANUARY: Computer modeling, done well, can inform decisions better than data analysis alone. An obvious statement? Well, maybe to some but it is disputed every day by others, especially staff at some government regulatory agencies I interact with.
  • FEBRUARY: It is possible that mRNA technology could cure or prevent herpes, malaria, flu, sickle cell anemia, cancer, HIV, Zika and Ebola (and obviously coronavirus). With flu and coronavirus, it may become possible to design a single shot that would protect against thousands of strains. It could also be used for nefarious purposes, and to protect against that are ideas about what a biological threat surveillance system could look like.
  • MARCH: I officially released my infrastructure plan for America, a few weeks before Joe Biden released his. None of the Sunday morning talk shows has called me to discuss so far. Unfortunately, I do not have the resources of the U.S. Treasury or Federal Reserve available to me. Of course, neither does he unless he can convince Congress to go along with at least some portion of his plans. Looking at his proposal, I think he is proposing to direct the fire hoses at the right fires (children, education, research, water, the electric grid and electric vehicles, maintenance of highways and roads, housing, and ecosystems. There is still no real planning involved, because planning needs to be done in between crises and it never is. Still, I think it is a good proposal that will pay off economically while helping real people, and I hope a substantial portion of it survives.
  • APRIL: Giant tortoises reach a state of “negligible senescense” where they simply don’t age for a long time. Humans are distant relatives of giant tortoises, so maybe we can aspire to this some day. They are not invulnerable to injury and disease.
  • MAY: An effective vaccine for malaria may be on the way. Malaria kills more children in Africa every year than Covid-19 killed people of all ages in Africa during the worst year of the pandemic. And malaria has been killing children every year for centuries and will continue long after Covid-19 is gone unless something is done.
  • JUNE: Masks, ventilation, and filtration work pretty well to prevent Covid transmission in schools. We should learn something from this and start designing much healthier schools and offices going forward. Design good ventilation and filtration into all buildings with lots of people in them. We will be healthier all the time and readier for the next pandemic. Then masks can be slapped on as a last layer of defense. Enough with the plexiglass, it’s just stupid and it’s time for it to go.
  • JULY: A new Lyme disease vaccine may be on the horizon (if you’re a human – if you are a dog, talk to your owner about getting the approved vaccine today.) I admit, I had to stretch a bit to find a positive story this month.
  • AUGUST: The Nordic welfare model works by providing excellent benefits to the middle class, which builds the public and political support to collect sufficient taxes to provide the benefits, and so on in a virtuous cycle. This is not a hopeful story for the U.S., where wealthy and powerful interests easily break the cycle with anti-tax propaganda, which ensure benefits are underfunded, inadequate, available only to the poor, and resented by middle class tax payers.
  • SEPTEMBER: Space-based solar power could finally be in our realistic near-term future. I would probably put this in the “interesting” rather than “hopeful” category most months, but I really struggled to come up with a hopeful story this month. I am at least a tiny bit hopeful this could be the “killer app” that gets humanity over the “dirty and scarce” energy hump once and for all, and lets us move on to the next layer of problems.
  • OCTOBER: The situation with fish and overfishing is actually much better than I thought.
  • NOVEMBER: Urban areas may have some ecological value after all.
  • DECEMBER: Covid-19 seems to be “disappearing” in Japan, or at least was before the Omicron wave. Maybe lessons could be learned. It seems possible that East Asian people have at least some genetic defenses over what other ethnic groups have, but I would put my money on tight border screening and an excellent public health care system. Okay, now I’m starting to feel a bit depressed again, sitting here in the U.S. where we can’t have these nice things thanks to our ignorant politicians.

Most interesting stories, that were not particularly frightening or hopeful, or perhaps were a mixture of both:

  • JANUARY: There have been fabulous advances in note taking techniques! Well, not really, but there are some time honored techniques out there that could be new and beneficial for many people to learn, and I think this is an underappreciated productivity and innovation skill that could benefit people in a lot of areas, not just students.
  • FEBRUARY: At least one serious scientist is arguing that Oumuamua was only the tip of an iceberg of extraterrestrial objects we should expect to see going forward.
  • MARCH: One study says 1-2 days per week is a sweet spot for working from home in terms of a positive economic contribution at the national scale. I think it is about right psychologically for many people too. However, this was a very theoretical simulation, and other studies attempting to measure this at the individual or firm scale have come up with a 20-50% loss in productivity. I think the jury is still out on this one, but I know from personal experience that people need to interact and communicate regularly for teams to be productive, and some people require more supervision than others, and I don’t think technology is a perfect substitute for doing these things in person so far.
  • APRIL: Hydrogen fuel cells may finally be arriving. Not so much in the U.S., where we can’t have nice things.
  • MAY: I learned about Lawrence Kohlberg, who had some ideas on the use of moral dilemmas in education.
  • JUNE: The big U.S. government UFO report was a dud. But what’s interesting about it is that we have all quietly seemed to have accepted that something is going on, even if we have no idea what it is, and this is new.
  • JULY: “Cliodynamics” is an attempt at a structured, evidence-based way to test hypotheses about history.
  • AUGUST: Ectogenesis is an idea for colonizing other planets that involves freezing embryos and putting them on a spaceship along with robots to thaw them out and raise them. Fungi could also be very useful in space, providing food, medicine, and building materials.
  • SEPTEMBER: Philip K. Dick was not only a prolific science fiction author, he also developed a comprehensive theory of religion which could possibly even be the right one. Also, possibly related but not really, if there are aliens out there they might live in creepy colonies or super-organisms like ants or termites.
  • OCTOBER: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?
  • NOVEMBER: Peter Turchin continues his project to empirically test history. In this article, he says the evidence points to innovation in military technologies being driven by “world population size, connectivity between geographical areas of innovation and adoption, and critical enabling technological advances, such as iron metallurgy and horse riding“. What does not drive innovation? “state-level factors such as polity population, territorial size, or governance sophistication“. As far as the technologies coming down the pike in 2022, one “horizon scan” has identified “satellite megaconstellations, deep sea mining, floating photovoltaics, long-distance wireless energy, and ammonia as a fuel source”.
  • DECEMBER: Time reminded us of all the industries Elon Musk has disrupted so far: human-controlled, internal-combustion-fueled automobiles; spaceflight; infrastructure construction (I don’t know that he has really achieved any paradigm shifts here, but not for lack of trying), “artificial intelligence, neurotechnology, payment systems and cryptocurrency.” I’m not sure I follow a couple of these, but I think they missed satellites.

Continuing Signs of U.S. Relative Decline

Signs of U.S. decline relative to our peer group of advanced nations are all around us. I don’t know that we are in absolute decline, but I think we are now below average among the most advanced countries in the world. We are not investing in the infrastructure needed in a modern economy just to reduce friction and let the economy function. The annual length of electric blackouts in the U.S. (hours) compared to leading peers like Japan (minutes) is just one telling indicator. In March, I looked at the Build Back Better proposal and concluded that it was more like directing a firehose of money at a range of problems than an actual plan, but I hoped at least some of it would happen. My rather low but not zero expectations were met, as some limited funding was provided for “hard infrastructure” and energy/emissions projects, but little or nothing (so far, as I write this) to address our systemic failures in health care, child care, or education. The crazy violence on our streets, both gun-related and motor vehicle-related, is another indicator. Known solutions to all these problems exist and are being implemented to various extents by peer countries. Meanwhile our toxic politics and general ignorance continue to hold us back. Biden really gave it his best shot – but if this is our “once in a generation” attempt, we are headed down a road where we will no longer qualify as a member of the pack of elite countries, let alone its leader.

The Climate Change, Drought, Food, Natural Disaster, Migration and Geopolitical Instability Nexus

2021 was a pretty bad year for storms, fires, floods, and droughts. All these things affect our homes, our infrastructure, our food supply, and our water supply. Drought in particular can trigger mass migration. Mass migration can be a disaster for human rights and human dignity in and of itself, and managing it effectively is difficult even for well-intentioned governments. But an insidious related problem is that migration pressure can tend to fuel right wing populist and racist political movements. We see this happening all over the world, and the situation seems likely to get worse.

Tipping Points and other Really Bad Things We Aren’t Prepared For

We can be thankful that nothing really big and new and bad happened in 2021. My apologies to anyone reading this who lost someone or had a tough year. Of course, plenty of bad things happened to good people, and plenty of bad things happened on a regional or local scale. But while Covid-19 ground on and plenty of local and regional-scale natural disasters and conflicts occurred, there were no new planetary-scale disasters. This is good because humanity has had enough trouble dealing with Covid-19, and another major disaster hitting at the same time could be the one that brings our civilization to the breaking point.

So we have a trend of food insecurity and migration pressure creeping up on us over time, and we are not handling it well even given time to do so. Maybe we can hope that some adjustments will be made there to get the world on a sustainable track. Even if we do that, there are some really bad things that could happen suddenly. Catastrophic war is an obvious one. A truly catastrophic pandemic is another (as opposed to the moderately disastrous pandemic we have just gone through.) Creeping loss of human fertility is one that is not getting much attention, but this seems like an existential risk if it were to cross some threshold where suddenly the global population starts to drop quickly and we can’t do anything about it. Asteroids were one thing I really thought we didn’t have to worry much about on the time scale of any human alive today, but I may have been wrong about that. And finally, the most horrifying risk to me in the list above is the idea of an accelerating, runaway feedback loop of methane release from thawing permafrost or underwater methane hydrates.

We are almost certainly not managing these risks. These risks are probably not 100% avoidable, but since they are existential we should be actively working to minimize the chance of them happening, preparing to respond in real time, and preparing to recover afterward if they happen. Covid-19 was a dress rehearsal for dealing with a big global risk event, and humanity mostly failed to prepare or respond effectively. We are lucky it was one we should be able to recover from as long as we get some time before the next body blow. We not only need to prepare for much, much worse events that could happen, we need to match our preparations to the likelihood of more than one of them happening at the same time or in quick succession.

Technological Progress

Enough doom and gloom. We humans are here, alive, and many of us are physically comfortable and have much more leisure time than our ancestors. Our social, economic, and technological systems seem to be muddling through from day to day for the time being. We have intelligence, science, creativity, and problem solving abilities available to us if we choose to make use of them. Let’s see what’s going on with technology.

Biotechnology: The new mRNA technology accelerated by the pandemic opens up potential cures for a range of diseases. We need an effective biological surveillance system akin to nuclear weapons inspections (which we also need) to make sure it is not misused (oops, doom and gloom trying to creep in, but there are some ideas for this.) We have vaccines on the horizon for diseases that have been plaguing us for decades or longer, like malaria and Lyme disease. Malaria kills more children worldwide, year in and year out, than coronavirus has killed per year at its peak.

Promising energy technologies: Space based solar power may finally be getting closer to reality. Ditto for hydrogen fuel cells in vehicles, although not particularly in the U.S. (I’m not sure this is preferable to electric vehicles for everyday transportation, but it seems like a cleaner alternative to diesel and jet fuel when large amounts of power are needed in trucking, construction, and aviation, for example.)

Other technologies: We are actually using technology to catch fish in more sustainable ways, and to grow fish on farms in more sustainable ways. We are getting better at looking for extraterrestrial objects, and the more we look, the more of them we expect to see (this one is exciting and scary at the same time). We are putting satellites in orbit on an unprecedented scale. We have computers, robots, artificial intelligence of a sort, and approaches to use them to potentially accelerate scientific advancements going forward.

The State of Earth’s Ecosystems

The state and trends of the Earth’s ecosystems continue to be concerning. Climate change continues to churn through the public consciousness and our political systems, and painful as the process is I think our civilization is slowly coming to a consensus that something is happening and something needs to be done about it (decades after we should have been able to do this based on the evidence and knowledge available.) When it comes to our ecosystems, however, I think we are in the very early stages of this process. This is something I would like to focus on in this blog in the coming year. My work and family life are busy, and I have decided to take on an additional challenge of becoming a student again for the first time in the 21st century, but somehow I will persevere. If you are reading this shortly after I write it in January 2022, here’s to good luck and prosperity in the new year!

October 2021 in Review

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Most frightening and/or depressing story: The technology (sometimes called “gain of function“) to make something like Covid-19 or something much worse in a laboratory clearly exists right now, and barriers to doing that are much lower than other types of weapons. Also, because I just couldn’t choose this month, asteroids can sneak up on us.

Most hopeful story: The situation with fish and overfishing is actually much better than I thought.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both: I thought about how to accelerate scientific progress: “[F]irst a round of automated numerical/computational experiments on a huge number of permutations, then a round of automated physical experiments on a subset of promising alternatives, then rounds of human-guided and/or human-performed experiments on additional subsets until you hone in on a new solution… [C]ommit resources and brains to making additional passes through the dustbin of rejected results periodically…” and finally “educating the next generation of brains now so they are online 20 years from now when you need them to take over.” Easy, right?

Covid-19 probably wasn’t made in a lab, but something like it could be at any time

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This Atlantic article is about a grant proposal to artificially create something very close to Covid-19 in a laboratory. Not to worry, it was not funded and it does not prove or disprove the “lab leak hypothesis”. Wait a minute, regardless of the lab leak hypothesis, what is chilling here is that the technology exists to create a Covid-like bioweapon or something even worse in a laboratory right now. This does not particularly surprise me, but it is scary. Even if we assume scientists in leading countries like the U.S. and China are relatively well regulated and have relatively high ethical standards, somewhere in the world there will be experts who are not as ethical and people willing to fund them. And over time, the technology will become more accessible to more people. And garage biotechnology will be harder to monitor and control than nuclear technology.

If I were spinning conspiracy theories here, I would say isn’t it an interesting coincidence that U.S. laboratories are set up to genetically engineer a Covid-19 if they want to, and U.S. laboratories also happened to have the vaccine for Covid-19 pretty much developed and ready to commercialize when needed. Hmm…I have no evidence of this and am not saying it is likely, I am just saying it is a story that would not be inconsistent with reality.