Tag Archives: innovation

vaccines without needles

New technology may deliver vaccines without needles. Actually, there are needles but they are so small and short you can’t feel them.

But with if a vaccine could be delivered by simply applying a patch? That’s Mark Prausnitz’s goal: creating a nickel-sized bandage-like device covered with 100 microscopic needles that would puncture the skin, then dissolve to get the vaccine into the body.

Maybe that sounds scary — 100 needles instead of one. But Prausnitz says you can’t really feel the needles. “It wouldn’t be like sandpaper or scratching,” he says. “You would have a hard time feeling a difference between the needles being there or not being there.”

April 2015 in Review

Negative stories:

Positive stories:

  • Mr. Money Mustache brought us a nice post on home energy efficiency projects. This was a very popular post.
  • Biotechnology may soon bring us the tools to seriously monkey with photosynthesis. (This is one of those stories where I struggle between the positive and negative columns, but clearly there is a potential upside when we will have so many mouths to feed.)
  • Donald Shoup, author of The High Cost of Free Parking, is retiring. That might sound bad, but his ground-breaking ideas are continuing on and actually seem to be going mainstream.
  • Lee Kuan Yew, who took Singapore “from third world to first” in one generation, passed away (in March, but I wrote about it in April. Let me be clear – I am an admirer and it is his life I am putting in the positive column, not his death.)
  • Donella Meadows explained how your bathtub is a dynamic system.
  • Robert Gordon offers a clear policy prescription for the U.S. to support continued economic growth.
  • I explain how a cap-and-trade program for stormwater and pollution producing pavement could work.
  • Joel Mokyr talks about advances in information technology, materials science and biotechnology.
  • Some U.S. cities are fairly serious about planting trees.
  • Edmonton has set a target of zero solid waste.
  • Saving water also saves energy. It’s highly logical, but if you are the skeptical type then here are some numbers. Also, urban agriculture reduces carbon emissions.
  • Peter Thiel thinks we can live forever. (positive, but do see my earlier comment about mouths to feed…)
  • A paper in Ecological Economics tries to unify the ecological footprint and planetary boundary concepts.
  • Philadelphia finally has bike share.

U.S. Innovation Deficit

MIT is warning that U.S. investment in R&D has dropped enormously. I find this idea very disturbing, that in an age of accelerating science and technology, which corporations and governments should have every incentive to take advantage of, they are failing to do so.

Declining U.S. federal government research investment — from just under 10 percent in 1968 to less than 4 percent in 2015 — in critical fields such as cybersecurity, infectious disease, plant biology, and Alzheimer’s are threatening an “innovation deficit,” according to a new MIT report to be released Monday, April 27.

U.S. competitors are increasing their investment in basic research. The European Space Agency successfully landed the first spacecraft on a comet. China developed the world’s fastest supercomputer and has done research in plant biology uncovering new ways to meet global food demand and address malnutrition. Meanwhile, U.S. investment in basic plant-related research and development is far below that of many other scientific disciplines, despite the fact that the agricultural sector is responsible for more than 2 million U.S. jobs and is a major source of export earnings.

The report, entitled “The Future Postponed: Why Declining Investment in Basic Research Threatens a U.S. Innovation Deficit,” highlights opportunities in basic research that could help shape and maintain U.S. economic power and benefit society.

 

Robert Gordon Revisited

In Robert Gordon’s chapter in the e-book Secular Stagnation: Facts, Causes and Cures, which I reviewed recently, he claims that he never said technological progress is slowing down, but only that future progress will be similar to the rate of the 1970s to now, not the faster rate that happened before the 1970s.

His main argument is that technology will not grow fast enough to offset economic “headwinds”, including population aging, inequality, government debt, and poor education. I don’t deny that these are all problems that we should be trying to address with better policy, and that addressing them would yield benefits. Gordon gives a policy presciption for the U.S. to address them:

My standard list of policy recommendations includes raising the retirement age in line with life expectancy, drastically raising the quotas for legal immigration, legalising drugs and emptying the prisons of non-violent offenders, and learning from Canada how to finance higher education. The US would be a much better place with a medical system as a right of citizenship, a value-added tax to pay for it, a massive tax reform to eliminate the omnipresent loopholes, and an increase in the tax rate on dividends and capital gains back to the 1993-97 Clinton levels.

However, where he doesn’t convince me is his argument that a constant rate of technological progress can’t lead to big gains. If the rate of increase in technology is constant in percentage terms, that means the level of technology is growing exponentially. We are constantly building on the advances of the past. There may be long periods when it seems like nothing is happening, but progress is actually happening behind the scenes, and then it suddenly seems to burst onto the commercial scene. Gordon actually talks about how the technologies that led to very fast productivity growth in the mid-20th century were actually inventions of the late 19th century (electricity, the telephone, etc.). It took a few decades for the technology to kick into everyday life. The 1970s to the present have been a time of huge advance in computer technology, so even if the lag times are not decreasing it should be about time for that to kick in. Biotechnology would be another couple decades behind, since the big advances in genomics started to happen in the 1990s. But there are reasons to be hopeful that the lag time between advances tends to decrease over time. So technology may be increasing not only at a constant percentage rate, which means exponential growth, but the rate of exponential growth itself may be accelerating. Ultimately, this lag time determines whether we are in for a lost decade or two as Gordon’s “headwinds” kick in before the next wave of technology-driven improvement. Of course, Gordon like most economists leaves out some other possible headwinds such as climate change, energy, and food, not to mention the really bad stuff like wars and pandemics.

Secular Stagnation

The “secular stagnation hypothesis” has now been around long enough that it has a nickname – SecStag. The basic idea is that the world may have entered a period of low economic growth that is going to persist for a long time, and governments need to start responding to it. This long ebook has chapters from a number of famous economists, including Larry Summers, Barry Eichengreen, Robert Gordon, Paul Krugman, and Edward Glaeser.

It’s hard for the non-economist to summarize, but I’ll try. Some of the ideas are:

  • The real interest rate is essentially the price of borrowing money. When people want to save (loan it out) more than other people want to borrow (invest it in new capital, infrastructure, inventions, business activity), it suggests that the rate of innovation, or profitable new investment possibilities, might have slowed down.
  • One way the rate of new profitable investments would slow down is if the rate of technological progress has slowed down compared to what it was over the past 50 years or so. Some are suggesting that.
  • Another possibility is that the type of technological progress that is occurring is harder to turn into profits than in the past, meaning it is not showing up in the traditional tracking numbers.
  • Another way is if governments are investing too little in infrastructure, and companies are investing too little in research and development because they are uncertain whether it will pay off.
  • Another way is if people are saving more for a rainy day, because there are more people nearing retirement as a fraction of the population than there used to be, and/or people and firms are saving because they are uncertain about the future, for example because they fear losing their jobs or having to may large health care bills.
  • Another possibility is that innovation is occurring, but only benefiting a few rich people and corporations at the top of the income scale, so that the average person is not benefiting.
  • A final possibility is that workers’ skills became obsolete because they were idle for too long after the recession hit. The idea that education is inadequate is also similar to this.

I think the explanation for the recent low GDP growth could be some combination of all of these, although I have a lot of trouble buying the lack of innovation hypothesis. Corporate profits and stock markets seem to be up, suggesting to me that profitable innovation is occurring but benefiting only a chosen few.

The automation vs. employment debate isn’t mentioned very much here, and climate change is mentioned only once in the 179 page book.

gene editing

Here is a long article in MIT Technology Review about gene editing.

“Germ line” is biologists’ jargon for the egg and sperm, which combine to form an embryo. By editing the DNA of these cells or the embryo itself, it could be possible to correct disease genes and to pass those genetic fixes on to future generations. Such a technology could be used to rid families of scourges like cystic fibrosis. It might also be possible to install genes that offer lifelong protection against infection, Alzheimer’s, and, Yang told me, maybe the effects of aging. These would be history-making medical advances that could be as important to this century as vaccines were to the last.

That’s the promise. The fear is that germ-line engineering is a path toward a dystopia of superpeople and designer babies for those who can afford it. Want a child with blue eyes and blond hair? Why not design a highly intelligent group of people who could be tomorrow’s leaders and scientists?…

All this means that germ-line engineering is much farther along than anyone imagined. “What you are talking about is a major issue for all humanity,” says Merle Berger, one of the founders of Boston IVF, a network of fertility clinics that is among the largest in the world and helps more than a thousand women get pregnant each year. “It would be the biggest thing that ever happened in our field,” he says. Berger predicts that repairing genes for serious inherited disease will win wide public acceptance, but beyond that, the technology would cause a public uproar because “everyone would want the perfect child” and it could lead to picking and choosing eye color and eventually intelligence. “These are things we talk about all the time,” he says. “But we have never had the opportunity to do it.”

How far out are practical applications in humans? Reading farther down, some are saying 10-20 years.

The Setup

I like this blog The Setup, even though it is obviously trying to sell me stuff. This particular post caught my eye because I have fantasies very similar to this, and I thought I was the only one:

I have a dream home all built in my mind. I want to buy a big square warehouse with 4 floors, each wide open from wall to wall. If it was a city block that would be fine. I would open the first floor to the public and have a bar/lounge/music venue. It would be a labyrinthine layout and the decor would be all hacked and repurposed, upcycled and somewhat robotic – a mad scientist bar! This would help to fund the second floor, which would be a wood/metal shop and a stop motion studio. We would have plenty of room to develop inventions and churn out animation as well as concoct fun and entertaining technological novelties for the bar downstairs.

The third floor would be a sweet pad for artists in residency. I would pick and choose different people from all walks of life to come and offer their creativity to the entire process. If I want to make some crazy scifi dream come to life, I could invite several experts from a variety of fields and have them all working together on that idea. That would be absolutely incredible – better than a superpower! I think the third floor would also probably have airhockey and skiiball as well.

The fourth floor would be my sort of living quarters. I would have a big kitchen and movie theater and dining room and all that stuff. It would be totally sweet and only a select few would get to come up there.

The roof, though, is the really special part. The roof would be my bedroom. I would have a man-made hill, with soft grass, under a geodesic dome like the biodome. I would have fruit trees and a vegetable garden. My bed would be dug right into the side of the hill so I could sleep under the stars. But also at the top of the hill, I would have a platform on a pneumatic lift that would raise my super high-tech telescope up into the bombardier’s bubble at the top of the dome. It would be so cool! I could sit down at the desk and hit a button and ascend to the highest point in the building to stargaze.

Sounds pretty good. My fantasy actually involves a chocolate factory. Seriously, there is an actual abandoned chocolate factory a few blocks from my house in Philadelphia that has been sitting vacant for decades, and is now up for auction.

Now, people are saying it’s going to go for about $10 million, so I need to raise that. There might be some asbestos in there that will need to come out. Then the renovations can begin. On the first floor, I’m going to recreate Philadelphia neighborhood bars and diners that have gone defunct over the years, using actual materials from them if they exist, otherwise just recreated from photos. So you can wander through the different rooms and each one will be a different recreated diner or bar. At least one will be a coffee shop open during the day. Then on the second floor will be offices of my foundation, the mission of which has not been established yet, but of course will have something to do with sustainability and doing something good for the world. Dogs will be allowed. The third floor will be apartments for visiting scholars and other interesting people. But as I will be fabulously wealthy, I will also just buy a bunch of nearby houses that interesting people can hang out in, including one for myself of course. Hey, it’s my fantasy.

what’s new with drugs

Drugs are not immune from the current wave of seemingly accelerating innovation (from Pacific Standard Magazine):

New psychoactive substances are coming out so quickly that it’s not possible to ban them fast enough to keep up, let alone police or scientifically understand them. When one substance is outlawed, another is born, just chemically distinct enough from the last one to evade its ban…

Not since the 19th century—when an earlier wave of globalization rapidly accelerated the spread of opium, cocaine, marijuana, and hazily defined “patent medicines”—has there been such a burgeoning and unregulated pharmacopeia. And by all indications, the future promises only more acceleration. Last year, a research lab at Stanford demonstrated that it’s possible to produce opioid drugs like morphine using a genetically modified form of baker’s yeast. Soon, even the production of traditional illegal drugs or illicit versions of pharmaceuticals could become a highly decentralized cottage industry, posing the same kind of regulatory challenge that the specter of 3-D printed firearms poses to the project of gun control.

In 2013, the U.N.’s World Drug Report summed up the global situation this way: “The international drug control system is floundering, for the first time, under the speed and creativity of the phenomenon known as new psychoactive substances.” Testifying before Congress that same year, the DEA’s Joseph Rannazzisi said that his agency could not keep up with “the clandestine chemists and traffickers who quickly and easily replace newly controlled substances with new, non-controlled substances.”

New Zealand is starting to regulate recreational drugs more like food: with labeling, consumer notices, and so on. Sometimes I wonder how long this will stay a mom and pop business – once it’s legal, won’t big drug and chemical companies try to get in on the game? It’s a brave new world.

February 2015 in Review

This blog got 173 hits in February! Pretty cool, considering I really just meant it as a place to collect my own scattered thoughts and refer back to them later. If 173 out of the 6 billion people out there like it, I am flattered. Okay, I understand there may have been a few repeat visitors. Also, judging from the most popular posts, there is one thing I mention occasionally that people really like: robots!

Negative trends and predictions:

  • Fresh Air had an interview with Elizabeth Kolbert, author of The Sixth Extinction. The idea here is that what humans are doing to other species is equivalent in scope to events that have killed off most life on Earth in the past.
  • The drought in the western U.S. continues to grind on.
  • There are some depressing new books out there about all the bad things that could happen to the world, from nuclear terrorism to pandemics. Also a “financial black hole”, a “major breakdown of the Internet”, “the underpopulation bomb”, the “death of death”, and more!
  • Government fragmentation explains at least part of suburban sprawl and urban decline in U.S. states, with Pennsylvania among the worst.

Positive trends and predictions:

  • Libraries are starting to go high-tech using warehouse robot technology.
  • I had a rambling post on technologies to watch: carbon fiber, the internet of things, self-driving cars and trucks, biotechnology for everything from carbon sequestration to cancer treatment to agriculture, and of course more automation, robots, and artificial intelligence. And yes, Clark W. Griswold’s cereal varnish is a real thing!
  • U.S. utility solar capacity is slowly ramping up.
  • A new study suggests a sudden, catastrophic climate tipping point may not be too likely.
  • Robots can independently develop new drugs.
  • According to Google, self-driving taxis are only 2-5 years away.
  • Complex ecosystems can be designed.
  • Compost toilets may save the world…if we can get over the ick factor and the sawdust problem.
  • There are lots of cheap new options for the aspiring high-tech handymen (and women and children) among us. Even better news, we may have reached the point where if you build a robot with your kid in the basement, and he then tells other kids about it, he might not get beat up on the playground.
  • New York City has some good examples of green stormwater infrastructure integrated in sidewalk and street design.

One thing that strikes me is that we keep hearing about biotechnology, but we haven’t seen big, obvious impacts in most of our daily lives yet. I suspect biotechnology is like computers and robots in the 70s, 80s, and 90s – slow but steady progress was being made in the background, the pressure was building, and then the wave suddenly broke onto the commercial and public consciousness. I suspect biotechnology is the next big wave that is going to break.

environmental regulations and profitability

If I understand this somewhat convoluted abstract from Ecological Economics correctly, empirical evidence shows that environmental regulation can actually increase corporate profitability by incentivizing innovation. The data also show that investors believe the exact opposite.

The Porter hypothesis asserts that properly designed environmental regulation motivates firms to innovate, which ultimately improves profitability. In this study, we test empirically the Porter hypothesis and the competing hypothesis that regulation undermines profitability (“costly regulation hypothesis”). In particular, we estimate the effect of clean water regulation, as reflected in the stringency of firm-specific effluent limits for two regulated pollutants, on the profitability of chemical manufacturing firms. As our primary contribution, we contrast the effect of clean water regulation on actual profitability outcomes and its effects on investors’ expectations of profitability. Our results for actual profitability are consistent with the Porter hypothesis, while our results for expected profitability are consistent with the costly regulation hypothesis. Thus, our empirical results demonstrate that investors do not appear to value the positive effect of tighter clean water regulation on actual profitability.