Tag Archives: biotechnology

more on the new cancer treatments

The BBC has a bit more on the leading edge in cancer research and treatment:

Cancer is entering a “new era” of personalised medicine with drugs targeted to the specific weaknesses in each patient’s tumour, say doctors…

The idea of precision medicine is to test every patient’s tumour, find the mutations that have become essential for it to survive and then select a targeted drug to counter-act the mutation – killing the tumour…

a revolution in genetics – allowing scientists to rapidly and cheaply interrogate a cancer’s corrupted DNA – is leading to huge excitement about a new generation of precision drugs.

May 2016 in Review

3 most frightening stories

  • There are scary and seemingly reckless confrontations going on between U.S. and Russian planes and ships in the Indian Ocean. And yet, it is bizarrely humorous when real life imitates Top Gun.
  • The situation in Venezuela may be a preview of what the collapse of a modern country looks like.
  • Obama went to Hiroshima, where he said we can “chart a course that leads to the destruction” of nuclear weapons, only not in his lifetime. Obama out.

3 most hopeful stories

3 most interesting stories

  • I try not to let this blog get too political, really I do. But in an election season I just can’t help myself. This is a blog about the future of civilization, and the behavior of U.S. political, bureaucratic, and military elites obviously has some bearing on that. In May I mused on whether the U.S. could possibly be suffering from “too much democracy“, Dick Cheney, equality and equal opportunity, and what’s wrong with Pennsylvania. And yes, I’ve said it before and I’ll say it again, TRUMP IS A FASCIST!
  • The world has about a billion dogs.
  • It turns out coffee grounds may not make good compost.

“the new war on cancer”

I remember that one of the (few) things that caught my attention in the last State of the Union address was talk of a new research plan to cure cancer. This article in The Week talks about what that is.

recently, researchers have had very encouraging results with a new approach called immunotherapy. Some patients in advanced stages of the disease, who previously would have been deemed terminal, have undergone rapid and complete recoveries. Hoping to build on that progress, President Obama in January announced a $1 billion “moonshot” to cure cancer, putting Vice President Joe Biden — whose son Beau died of brain cancer last year — in charge of “mission control.” …

Another promising new frontier is genetic analysis, which splits each type of cancer into dozens of subtypes, so that specific chemotherapy drugs can be tailored to each cancer. Experts also now hope they can use the breakthrough gene-editing technique called CRISPR to correct mutations in cancer cells, or perhaps “edit” out mutation-prone genes that people inherit…

In August 2015, former President Jimmy Carter announced he had been diagnosed with advanced melanoma, a type of skin cancer that had spread to his liver and brain. “I’m perfectly at ease with whatever comes,” said Carter, then 90. Four months later, Carter announced he was cancer-free. Along with radiation, Carter had been put on pembrolizumab (brand name Keytruda), a checkpoint inhibitor that stops cancer cells from blocking the immune system’s response. Soon after, Carter’s scans showed no evidence of the original cancer lesions on his brain, or any new lesions. Given that cancer can often reappear years down the line, oncologists prefer to talk in terms of “years of remission” rather than “cure” — but like Carter, some cancer patients on Keytruda have seen their disease disappear completely. Not surprisingly, says melanoma specialist Dr. Patrick Ott, Carter’s miraculous recovery has prompted patients across the country to demand, “I want what Jimmy Carter had.” Doctors caution that in clinical trials, Keytruda shrank the tumors in only 24 percent of patients, and that it only works on certain types of cancer.

April 2016 in Review

3 most frightening stories

  • The U.S. government’s dominant ideology of free trade and globalization may have roots in U.S. government propaganda designed to provide hidden subsidies to Japan and Korea, our Cold War allies in Asia. And resulting financial deregulation in the 1990s may have been the beginning of the end for the U.S. empire.
  • A new study says that ice melting in Antarctica could double sea level rise projections in the long term. Meanwhile, in the short term, the drought in Southeast and South Asia is getting more and more severe.
  • Robert Paxton says Trump is pretty much a fascist. Although conditions are different and he doesn’t believe everything the fascists believed. Umberto Eco once said that fascists don’t believe anything, they will say anything and then what they do once in office has nothing to do with what they said.

3 most hopeful stories

  • Brookings has a new report on encouraging innovation in the water sector. A lot of it is just about charging more, and it should be fairly obvious why that is politically controversial even if it is the right thing economically. But the report did have an explanation of decoupling (p. 28) which I found helpful. Decoupling is an answer to the puzzle of how a utility can support conservation without losing its revenue base.
  • The U.S. Department of Energy says the technical potential of solar panels is to supply about 39% of all energy use. And electric cars may be about to come roaring back in a big way.
  • Better management of agricultural soil might be able to play a big role in carbon sequestration.

3 most interesting stories

The Windup Girl

Another book I’m reading (actually listening to) right now is the The Windup Girl by Paolo Bacigalupi. This is biopunk, possibly my favorite genre when it is done well. I won’t spoil the plot below, but I’ll tell you some of the background on what is going on in the society about halfway through the book, so if you prefer to read it and discover this gradually, then stop reading now!

The interesting thing about this society (Southeast Asia, supposedly about 100 years in the future), is that it has very advanced scientific and technological knowledge compared to our current society, and yet it is extremely energy and resource poor compared to our current society. All food seems to be genetically engineered by a few western companies (“calorie companies”). At some point there has been a catastrophic loss of biodiversity. At the point in the book where I am now, there are hints that these companies themselves have engineered the pests and diseases that brought this about. We don’t know why – maybe as a form of competition to attack each others products, or maybe to attack non-genetically engineered organisms. Whatever the original strategy, these plagues have devastated natural ecosystems and come back to attack the company crops themselves, and also to sometimes jump to humans, so that everyone is sick and starving and the companies are trying to hunt down any surviving stashes of biodiversity.

The society is also extremely energy poor. Climate change and sea level rise have been devastating, and fossil fuels seem to be entirely gone with the exception of coal, the latter rare and used only by the government for pumping in a last-ditch effort to keep the ocean at bay. There is some methane available from digesting animal manure, again tightly controlled by the government. For mobile power, they wind “springs” using animal power, including “megadonts” which sound like reconstituted mammoths. I have a couple questions on plausibility here, neither of which detracts from the story which I am really enjoying. First, which such advanced biological technology developed over 100 years, it is surprising not to see solar power, wind power, fuel cells, or even nuclear power. In fact, there seems to be no form of electricity at all. Second, I imagine mammoths would eat a lot. Let’s say you grow food, feed the mammoths, have them wind the springs, then digest their manure to obtain methane all very efficiently. I find it hard to believe that if you took whatever you are feeding the mammoths and digested it directly, you would not obtain more energy. The exception might be if the mammoths go foraging themselves and eat something that grows naturally on land that will not grow anything else, and that particular plant is digestible by mammoths but not by methane-generating bacteria. With a very limited range of plants available, maybe this is not all that implausible in the bizarre universe of this book.

containing technologies

This post is about CRISPR and gene drive, which are interesting in their own right. What I am going to quote is the author’s ideas on how to develop a promising but potentially dangerous technology responsibly:

For starters, public notification and broadly inclusive discussions should always precede and inform development of gene drive interventions in the lab. A clear description of the potential impact of an experiment – as my colleagues and I have provided for the technology as a whole – must be followed by transparency throughout the development process. This community-guided approach to research provides opportunities to identify and address potential problems and concerns during development. If a perceived problem cannot be adequately addressed, researchers should be prepared to terminate the project…

Another feature of a responsible approach would be a commitment by scientists to evaluate each proposed gene drive intervention – say, immunizing mice so that they cannot transmit Lyme disease to ticks – individually, rather than making a blanket decision on the technology as a whole. After all, the benefits and risks of each intervention would be entirely different.

A final safeguard against the irresponsible development of gene drive technology is to ensure that early interventions are developed exclusively by governments and nonprofit organizations. Given the potential of financial incentives to skew the design and results of safety tests, keeping the profit motive out of the development and decision-making processes will encourage balanced assessments.

January 2016 in Review

I’m going to try picking the three most frightening posts, three most hopeful posts, and three most interesting posts (that are not particularly frightening or hopeful) from January.

3 most frightening posts

  • Paul Ehrlich is still worried about population. 82% of scientists agree.
  • Thomas Picketty (paraphrased by J. Bradford Delong) says inequality and slow growth are the norm for a capitalist society. Joseph Stiglitz has some politically difficult solutions: “Far-reaching redistribution of income would help, as would deep reform of our financial system – not just to prevent it from imposing harm on the rest of us, but also to get banks and other financial institutions to do what they are supposed to do: match long-term savings to long-term investment needs.”
  • Meanwhile, government for and by big business means the “Deep State” is really in control of the U.S. In our big cities, the enormous and enormously dysfunctional police-court-prison system holds sway over the poor.

3 most hopeful posts

3 most interesting posts

  • There are some arguments in favor of genetically modified food – they have increased yields of some grains, and there is promise they could increase fish yields. 88% of scientists responding to a Pew survey said they think genetically modified food is safe, but only 37% of the U.S. public thinks so. In other biotech news, Obama’s State of the Union announced a new initiative to try to cure cancer. In other food news, red meat is out.
  • Not only is cash becoming obsolete, any physical form of payment at all may become obsolete.
  • The World Economic Forum focused on technology: “The possibilities of billions of people connected by mobile devices, with unprecedented processing power, storage capacity, and access to knowledge, are unlimited. And these possibilities will be multiplied by emerging technology breakthroughs in fields such as artificial intelligence, robotics, the Internet of Things, autonomous vehicles, 3-D printing, nanotechnology, biotechnology, materials science, energy storage, and quantum computing.”

 

SOTU

I’ll pull out a few quotes from Obama’s State of the Union that are relevant to the theme of this blog.

First, automation and globalization:

Today, technology doesn’t just replace jobs on the assembly line, but any job where work can be automated. Companies in a global economy can locate anywhere, and they face tougher competition. As a result, workers have less leverage for a raise. Companies have less loyalty to their communities. And more and more wealth and income is concentrated at the very top.

What automation and globalization have in common is that if you are a relatively low-skilled worker in a relatively high-income country like the U.S., there is a risk your job could be replaced either by a computer (automation) or a low-skilled worker in a low-income country (globalization). Where they differ is that automation is starting to squeeze those low-skilled workers in the low-income countries too, and gradually it will also start to squeeze the higher-skilled workers in the higher-income countries. Obama’s solutions to all this – education and training, unemployment and wage insurance, healthcare and childcare benefits to make employment more flexible, lowering barriers to entrepreneurship, are the obvious ones, but we’ve been tinkering with these things for a long time with only slow progress, and the trends are only going to accelerate.

Second, biotechnology and genetics:

Last year, Vice President Biden said that with a new moonshot,America can cure cancer. Last month, he worked with this Congress to give scientists at the National Institutes of Health the strongest resources that they’ve had in over a decade. (Applause.) So tonight, I’m announcing a new national effort to get it done…let’s make America the country that cures cancer once and for all.

This seems to be a nod to biomedical research and biotech more generally, which I am convinced is the next big technology revolution akin to the information revolution we have been going through over the past few decades.

Next, climate change and fossil fuels:

Now we’ve got to accelerate the transition away from old, dirtier energy sources. Rather than subsidize the past, we should invest in the future — especially in communities that rely on fossil fuels. We do them no favor when we don’t show them where the trends are going. That’s why I’m going to push to change the way we manage our oil and coal resources, so that they better reflect the costs they impose on taxpayers and our planet. And that way, we put money back into those communities, and put tens of thousands of Americans to work building a 21st century transportation system.

Actually, I am not sure what he is talking about here. I would support a revenue-neutral carbon tax, with the proceeds invested in education, training, research and/or infrastructure. But I’m only speculating. If there was some initiative announced along these lines I missed it.

Finally, corruption in U.S. politics:

We have to reduce the influence of money in our politics, so that a handful of families or hidden interests can’t bankroll our elections. (Applause.) And if our existing approach to campaign finance reform can’t pass muster in the courts, we need to work together to find a real solution — because it’s a problem… Those with money and power will gain greater control over the decisions that could send a young soldier to war, or allow another economic disaster, or roll back the equal rights and voting rights that generations of Americans have fought, even died, to secure.

This is pretty vague. I would support a constitutional amendment to clarify that a person is a human being and a human being is a person. Human beings should have the right to free political speech, but corporations and other special interest legal entities should not. The law can be written to preserve the important rights corporations do have that create a fair and predictable playing field for businesses to compete – equal protection under the law, access to the courts, protection from arbitrary seizure of property, and so forth. But the richest and most powerful shouldn’t be able to buy politicians and write the rules of the game unfairly in their favor.

On the possibility of those right-wing self-interested corporate entities joining forces with right-wing grass roots impulses, resulting in something truly ugly:

But if we give up now, then we forsake a better future.  And then, as frustration grows, there will be voices urging us to fall back into our respective tribes, to scapegoat fellow citizens who don’t look like us, or pray like us, or vote like we do, or share the same background.

I wouldn’t have believed that was likely a year ago, but here we are approaching the official beginning of an election season that is turning out to be very surprising, with Obama riding off into the sunset.

2015 Year in Review

I’m going to try picking the most frightening, most hopeful, and most interesting post from each month. If the most interesting is also the most frightening or most hopeful, I’ll pick the next most interesting. Then I’ll have 12 nominees in each category and I’ll try to pick the most frightening, hopeful, and interesting posts of the year.

JANUARY

Most frightening: Johan Rockstrom and company have updated their 2009 planetary boundaries work. The news is not getting any better. 4 of the 9 boundaries are not in the “safe operating space”: climate change, loss of biosphere integrity, land-system change, altered biogeochemical cycles (phosphorus and nitrogen).

Most hopeful: It is starting to seem politically possible for the U.S. to strengthen regulation of risk-taking by huge financial firms.

Most interesting: Taxi medallions have been called the “best investment in America”, but now ride-sharing services may destroy them.

FEBRUARY

Most frightening: There are some depressing new books out there about all the bad things that could happen to the world, from nuclear terrorism to pandemics. Also a “financial black hole”, a “major breakdown of the Internet”, “the underpopulation bomb”, the “death of death”, and more!

Most hopeful: A new study suggests a sudden, catastrophic climate tipping point may not be too likely.

Most interesting: Government fragmentation explains at least part of suburban sprawl and urban decline in U.S. states, with Pennsylvania among the worst.

MARCH

Most frightening: The drought in California and the U.S. Southwest is the worst ever, including one that wiped out an earlier civilization in the same spot. At least it is being taken seriously and some policies are being put in place. Meanwhile Sao Paulo, Brazil is emerging as a cautionary tale of what happens when the political and professional leadership in a major urban area fail to take drought seriously. Some people are predicting that water shortages could spark serious social unrest in developing countries.

Most hopeful: If we want to design ecosystems or just do some wildlife-friendly gardening, there is plenty of information on plants, butterflies, and pollinators out there. There is also an emerging literature on spatial habitat fragmentation and how it can be purposely designed and controlled for maximum benefit.

Most interesting (I just couldn’t choose between these):

  • Innovation in synthetic drugs is quickly outpacing the ability of regulatory agencies to adapt. (I struggled whether to put this in the negative or positive column. Drugs certainly cause suffering and social problems. But that is true of legal tobacco and alcohol, and prescription drugs, as well as illegal drugs. The policy frameworks countries have used to deal with illegal drugs in the past half century or so, most conspicuously the U.S. “war” on drugs, have led to more harm than good, and it is a good thing that governments are starting to acknowledge this and consider new policies for the changing times.)
  • Germ-line engineering is much further along than anyone imagined.” This means basically editing the DNA of egg and sperm cells at will. I put this in the positive column because it can mean huge health advances. Obviously there are risks and ethical concerns too.

APRIL

Most frightening: A group of well-known economists is concerned that the entire world has entered a period of persistently low economic growth, or “secular stagnation“.

Most hopeful: Donald Shoup, author of The High Cost of Free Parking, is retiring. That might sound bad, but his ground-breaking ideas are continuing on and actually seem to be going mainstream.

Most interesting:

  • Biotechnology may soon bring us the tools to seriously monkey with photosynthesis. (This is one of those stories where I struggle between the positive and negative columns, but clearly there is a potential upside when we will have so many mouths to feed.)
  • Peter Thiel thinks we can live forever. (positive, but do see my earlier comment about mouths to feed…)

MAY

Most frightening: We’ve hit 400 ppm carbon dioxide in the atmosphere, not just some places sometimes but pretty much everywhere, all the time.

Most hopeful: The rhetoric on renewable energy is really changing as it starts to seriously challenge fossil fuels on economic grounds. Following the Fukushima disaster, when all Japan’s nuclear reactors were shut down, the gap was made up largely with liquid natural gas and with almost no disruption of consumer service. But renewables also grew explosively. Some are suggesting Saudi Arabia is supporting lower oil prices in part to stay competitive with renewables. Wind and solar capacity are growing quickly in many parts of the world.Lester Brown says the tide has turned and renewables are now unstoppable.

Most interesting: Human chemical use to combat diseases, bugs, and weeds is causing the diseases, bugs and weeds to evolve fast.

JUNE

Most frightening: One estimate says that climate change may reduce global economic growth by 3% in 2050 and 7-8% by 2100. Climate change may also double the frequency of El Nino. The DICE model is available to look at climate-economy linkages. Dennis Meadows and Jorgen Randers describe what a coming long, slow decline might look like. Rising temperatures in the Arctic are drying things out, leading to more fires, which burns more carbon, which raises temperatures, in an accelerating feedback loop.

Most hopeful: Stock values of U.S. coal companies have collapsed.

Most interesting: According to Paul Romer, academic economics has lost its way and is bogged down in “mathiness”.

JULY

Most frightening: James Hansen is warning of much faster and greater sea level rise than current mainstream expectations.

Most hopeful: Edible Forest Gardens is a great two book set that lays out an agenda for productive and low-input ecological garden design in eastern North America. You can turn your lawn into a food forest today.

Most interesting:

AUGUST

Most frightening: Steven Hawking is worried about an artificial intelligence arms race starting “within years, not decades”.

Most hopeful: It may be possible to capture atmospheric carbon and turn it into high-strength, valuable carbon fiber. This sounds like a potential game-changer to me, because if carbon fiber were cheap it could be substituted for a lot of heavy, toxic and energy-intensive materials we use now, and open up possibilities for entirely new types of structures and vehicles.

Most interesting:

  • gene drive” technology helps make sure that genetically engineered traits are passed along to offspring.
  • Technology marches on – quantum computing is in early emergence, the “internet of things” is arriving at the “peak of inflated expectations”, big data is crashing into the “trough of disillusionment”, virtual reality is beginning its assent to the “plateau of productivity”, and speech recognition is arriving on the plateau. And super-intelligent rodents may be on the way.
  • Robotics may be on the verge of a Cambrian explosion, which will almost certainly be bad for some types of jobs, but will also bring us things like cars that avoid pedestrians and computer chips powered by sweat. I for one am excited to be alive at this moment in history.

SEPTEMBER

Most frightening: Climate may be playing a role in the current refugee crisis, and the future may hold much more of this.

Most hopeful: The right mix of variety and repetition might be the key to learning.

Most interesting: Edward Tufte does not like Infographics.

OCTOBER

Most frightening: Corrupt Russian officials appear to be selling nuclear materials in Moldova.

Most hopeful: Elephants seem to have very low rates of cancer. Maybe we could learn their secrets.

Most interesting: Stephen Hawking is worried about inequality and technological unemployment.

NOVEMBER

Most frightening: I noticed that Robert Costanza in 2014 issued an update to his seminal 1997 paper on ecosystem services. He now estimates their value at $125 trillion per year, compared to a world economy of $77 trillion per year. Each year we are using up about $4-20 trillion in value more than the Earth is able to replenish. The correct conclusion here is that we can’t live without ecosystem services any time soon with our current level of knowledge and wealth, and yet we are depleting the natural capital that produces them. We were all lucky enough to inherit an enormous trust fund of natural capital at birth, and we are spending it down like the spoiled trust fund babies we are. We are living it up, and we measure our wealth based on that lifestyle, but we don’t have a bank statement so we don’t actually know when that nest egg is going to run out.

Most hopeful: There are plenty of ways to store intermittent solar and wind power so they can provide a constant, reliable electricity source.

Most interesting: Asimov’s yeast vats are finally here. This is good because it allows us to produce food without photosynthesis, but bad because it allows us to produce food without photosynthesis.

DECEMBER

Most frightening: Cyberattacks or superflares could destroy the U.S. electric grid.

Most hopeful: We had the Paris agreement. It is possible to be cynical about this agreement but it is the best agreement we have had so far.

Most interesting: I mused about whether it is really possible the U.S. could go down a fascist path. I reviewed Robert Paxton’s five stages of fascism. I am a little worried, but some knowledgeable people say not to worry. After reading Alice Goffman’s book On the Runthough, one could conclude that a certain segment of our population is living in a fascist police state right now. There is some fairly strong evidence that financial crises have tended to favor the rise of the right wing in Europe.

DISCUSSION

Well, one thing that certainly jumps out on the technology front is biotechnology. We have a couple articles about the possibility of drastic increases in the human lifespan, and what that would mean. “Germ-line engineering”, “gene drive”, and “CRISPR” are all ways of monkeying with DNA directly, even in ways that get passed along to offspring. To produce more food, we may be able to monkey with the fundamentals of photosynthesis, and if that doesn’t work we can use genetically engineered yeast to bypass photosythesis entirely.

At the risk of copyright infringement, I am reproducing the “Gartner hype cycle” below, which was mentioned in one of the posts from August.

Gartner Hype Cycle

Gartner Hype Cycle

Government and corporate labs have been making huge advances in biotechnology in the last decade or so, so it is well beyond the “innovation trigger”. It has not yet reached the “peak of inflated expectations” where it would explode onto the commercial and media scene with a lot of fanfare. I expect that will happen. We will probably see a biotech boom, a biotech bubble, and a biotech bust similar to what we saw with the computers and the internet. And then it will quietly pervade every aspect of our daily lives similar to computers and the internet, and our children will shrug and assume it has always been that way.

Obviously there are dangers. A generation of people that refuse to die on time would be one. Bioterrorism is obviously one. Then there is the more subtle matter that as we raise the limit on the size our population and consumption level can attain, the footprint of our civilization will just grow to meet the new limit. When and how we come up against these limits, and what to do about it, is the subject of the updates to two seminal papers on these issues, by Rockstrom and Costanza. We have entered an “unsafe operating space” (Rockstrom), where we are depleting much more natural capital each year than the planet can replenish (Costanza), and there will be consequences. The Paris agreement is one hopeful sign that our civilization might be able to deal with these problems, but even if we deal with the carbon emission problem, it might be too late to prevent the worst consequences, and there are going to be “layers of limits” as the authors of Limits to Growth put it all those decades ago. If we take care of the global warming problem and figure out a way to grow food for 50 billion people, eventually we will grow to 50 billion people and have to think of something else.

So without further ado:

Most frightening: I can’t pick just one. In the relatively near term, it’s the stalling out of the world economy; the convergence of climate change, drought, and the challenge of feeding so many people; and the ongoing risks from nuclear and biological weapons.

Most hopeful: I see some hope on energy and land use issues. The Paris agreement, combined with renewable energy and energy storage breakthroughs, the potential for much more efficient use of space in cities rather than letting cars take up most of the space, are all hopeful. The possibility of making carbon fiber out of carbon emissions is a particularly intriguing one. At my personal scale, I am excited to do some sustainable gardening of native species that can feed both people and wildlife. I don’t expect my tiny garden to make a major difference in the world, but if we all had sustainable gardens, they were all connected, and we weren’t wasting so much space on roads and parking, it could start adding up to a much more sustainable land use pattern.

Most interesting: I’ve already mentioned a lot of stuff, so I will just pick something I haven’t already mentioned in the discussion above: the rise of synthetic drugs. It’s just an interesting article and makes you think about what it will mean to have advanced chemical, information, and biological technologies in the hands of the little guy, actually many, many little guys. It is a brave, new, dangerous, exciting world indeed. Happy new year!

December 2015 in Review

Now it’s time to review December 2015, before we get on to reviewing 2015 as a whole.

Negative stories (-10):

  • Some car dealers are deliberately talking customers out of buying electric cars that they want, because the car dealer will make less money on oil changes. (-1)
  • Breaking news: we can’t believe everything we hear on the internet. Some of it is deliberate government and corporate propaganda, and some is “online filter bubbles” or marketing algorithms telling each of us only what we want to hear. Data used by all these algorithms is becoming more and more valuable. (-1)
  • Cyberattacks or superflares could destroy the U.S. electric grid. (-1)
  • Guns cause gut-wrenching, accidental deaths of children quite frequently in the U.S. The U.S. has a rate of violent assault 5-10 times higher than our close Anglo-American cousins, which in turn have higher rates than most of Europe and developed Asia. (-1)
  • I mused about whether it is really possible the U.S. could go down a fascist path. I reviewed Robert Paxton’s five stages of fascism. I am a little worried, but some knowledgeable people say not to worry. After reading Alice Goffman’s book On the Run though, one could conclude that a certain segment of our population is living in a fascist police state right now. There is some fairly strong evidence that financial crises have tended to favor the rise of the right wing in Europe. (-2)
  • After more than a decade of drought, there may not be enough water to sustain both Lake Powell and Lake Mead in the U.S. desert southwest. Some are suggesting draining Lake Powell. (-1)
  • This year’s “super El Nino” might have happened with or without climate change, but climate change made it more likely. I have to admit though I enjoyed sitting on my front porch in shorts on Christmas here in Philadelphia. (-1)
  • Jeffrey Sachs makes a pretty good case that the rise of violent religious fanaticism in the Middle East is largely the CIA’s fault. (-2)

Positive stories (+13):

    • Las Vegas is planning to go all renewable by 2017, mostly centralized solar. (+1)
    • Children have a natural aptitude for learning to recognize patterns. Now all we have to do is figure out which patterns we should be teaching them to recognize. (+1)
    • Some U.S. Presidential candidates want to invest in infrastructure, which is good. A national infrastructure plan might also be good. (+1)
    • Ericcson released some technology predictions for 2016 and beyond: Artificial intelligence will start to assist us without the need for smartphone screens. Virtual reality will start to come into its own for tech support, sports, dating, and shopping. And we will start to see more sensors embedded in our homes and eventually our bodies. (+1)
    • Trends in Ecology and Evolution made some technology predictions too: “managed bees as transporters of biological control agents, artificial superintelligence, electric pulse trawling, testosterone in the aquatic environment, building artificial oceanic islands, and the incorporation of ecological civilization principles into government policies in China”. (+1)
    • A serious but treatable infection can destroy a tumor. (+1)
    • Self-driving cars could drastically reduce the amount of land required for parking in cities. There are some moves toward car-free central cities around the world. (+3)
    • We had the Paris agreement. It is possible to be cynical about this agreement but it is the best agreement we have had so far. (+2)
    • New York City recently finished planting a million trees. (+2)

So we end the year on a positive note!