Author Archives: rdmyers75@hotmail.com

genetic engineering and coronavirus vaccines

Some of the coronavirus candidates are being developed using tech such as chicken eggs that have been around for a while (no, I don’t know which one came first…) But there are also some cutting edge genetic engineering technologies being applied to commercial vaccine development for the first time.

The gene-based vaccines (several based on messenger RNA, and which I’ll refer to as mRNA vaccines from here on out) are novel and promising because of the speed with which they can be designed and scaled for manufacturing, but none has ever been licensed for use to combat a disease. The mRNA candidates inject genetic coding from the SARS-CoV-2 virus into the vaccinee, which then induces the body to create part of the virus to attack with an immune response. In other words, through genetic coding, the body itself produces a component of the pathogen, which then primes the body to attack the full virus if it later presents itself.

Viral vector vaccines using adenoviruses are also more novel than traditional vaccine platforms. Viral vector vaccines use a genetically engineered virus that is not the vaccine target to deliver into the cells of a vaccinee the genetic instructions to produce a protein of the targeted virus, which then induces an immune response. The European Medicines Agency (Europe’s counterpart to the U.S. Food and Drug Administration) recently approved an adenovirus vaccine (with a booster) for the prevention of Ebola.

AEI

I remember reading in the past that new techniques like these should be applied to vaccine development, but weren’t being because the sure-fire profit motive wasn’t there for the big drug companies. I guess tens of billions of dollars in government funding changed that in a matter of months. The good thing is we will have this technology up and running going forward. The bad thing is it sounds a little scary if it were to fall into the wrong hands.

if the universe is a simulation, can it crash?

Hopefully, if the universe is a simulation, it is a stable one. And if it crashes, whatever intelligent entity is out there can call his or her IT guy, spin it up again, fast forward to where it left off, and we won’t know the difference. If it is a simulation, do we really want to know? This article in Scientific American says that if we really want to know, one way to test whether it is a simulation is to try to crash it on purpose. So how would you do that? One way is to build our own simulated universes, then let them build their own simulated universes, and so on. At some point, the hardware of our universe should not be able to run all those universes. So to get to this point, we need to keep working on building way faster computers.

the numbers on maternal mortality

The site Our World in Data likes to plot various statistics against GDP per capita. The U.S. is almost always below the middle, and sometimes towards the bottom, of the industrialized countries. On maternal mortality, the U.S. is orders of magnitude safer than many poor countries, but like other stats there is a noticeable gap with the leaders in our peer group (Finland, Iceland, France, Japan, Switzerland to name a few). Greece and Poland stand out as middle income countries that do much better than us. Interestingly, Belarus also stands out as a high-performance, lower-income country on this metric. The plot is animated, so you can see the U.S. drifting slightly worse over time even as our wealth grows, and even as other countries tend to make progress over time. I think I’ve said it before – we’re coasting on fumes, drifting behind the middle of the pack, and continuing to lose momentum.

robotic fighter planes

Robotic fighter planes are here. I remember reading one article (which I can’t find at the moment) about a test where human pilots were unable to beat them in a simulation. The simulation is unimportant, because the robots were unconstrained and allowed to sacrifice themselves if that gave them the greatest chance of taking out the enemy fighter. And that is just what they did – play chicken with the human pilots, whose instinct was to try to preserve themselves and their expensive planes. Anyway, here is another article from Forbes about a “robotic wingman” called Skyborg. Beyond the apocalyptic name (Terminator bad guys meet Star Trek bad guys?), the article focuses on intricacies of Pentagon procurement. Suffice it to say, the companies involved (who probably issued a press release that led to this article) hope there will be lots of procurement.

modern monetary models

These two posts have a long explanation of monetary theory in general, and modern monetary theory in particular. It’s a little over my head, although I like challenging myself to try to understand it. It is a very abstract system to try to understand. I think that if you can understand monetary policy, you might have a chance to understand what money actually is. And if enough people understand it, they might stop believing in it and the world might end.

Basically, as I understand it, the government prints money (i.e., borrows money from itself) and spends it, usually more than it takes back in taxes, and this creates a surplus in the private sector. It can control the money supply by changing the amount it borrows and spends, or by changing the tax rate. I think what people find scary about “modern monetary theory” is that it suggests money doesn’t have to be taken seriously and any needed amount can just be printed any time. This is why politicians generally have not been given the keys to the printing press.

I have a metaphor in my mind of the real economy as a machine with pistons and gears turning. The fuel for the machine is maybe human effort and ideas (and some actual fuel). But the gears will grind without grease, so you have to lube it up. Not enough and the system will shut down violently. Adding extra will not make the machine turn faster, but it will not do any serious harm other than maybe a gunky mess someone has to clean up. Better to use a little too much lube than not enough. The lube for the economic machine is money.

There were a few other interesting things in the articles that I didn’t know or hadn’t thought about recently. It refers to the late Wynne Godley at Cambridge University as the “father of stock-flow consistent modeling”. I think a few people in a few different disciplines might claim that mantle, but that is the neat thing about system theory, it’s interdisciplinary. There is a certain irony if anyone is into it and doesn’t realize it is interdisciplinary.

There is a free(?) system dynamics system called Minsky, something like Stella but tailored specifically to finance and economics. Matlab also has a sort of stock-flow simulation module call Simulink that I hadn’t heard of. I am still waiting for that system dynamics R package.

The Minsky model also made me think of the late Jay Forrester, who advocated for a long time for stock-flow modeling in economics.

Traditional mainstream academic economics, by trying to be a science, has failed to answer major questions about real- life economic behavior. Economics should become a systems profession, such as management, engineering, and medicine. By closely observing the structures and policies in business and government, simulation models can be constructed to answer questions about business cycles, causes of major depressions, inflation, monetary policy, and the validity of descriptive economic theories. A system dynamics model, as a general theory of economic behavior, now endogenously generates business cycles, Kuznets cycles, the economic long wave, and growth. A model is a theory of the behavior that it generates. The economic model provides the theory, thus far missing from economics, for the Great Depression of the 1930s and how such episodes can recur 50–70 years apart. Simpler system dynamics models can become the vehicle for a relevant and exciting pre-college economics education.

Jay Forrester, quoted in a blog called Viewpoints that Matter (including the blogger’s viewpoint, presumably)

Imagine if the average high school graduate really had an intuitive understanding of how important systems like the economy are structured and why they function the way they do as a result. The world might be a different place.

I’ve been working on one more metaphor for awhile. Maybe the real economy is like a tightrope, and the financial economy is like a safety net stretched above a concrete floor. If we use too much food, water, energy, saturate the atmosphere and ocean with our waste, etc. we will fall off the rope. Hitting the concrete floor would be a failure of the real economy like starvation or freezing to death. The safety net would be a spike in prices for food or energy that slows down the economy short of (most people, right away) actually dying of exposure. The fall would still be very painful and you might break bones or even your neck if you fall just the wrong way. What about something like nuclear proliferation or all the ice in Antarctica suddenly melting? I don’t know, maybe dry rot in the old net that we are failing to do anything about. No price signal is going to save us from those.

Senate Democrats’ Special Committee on the Climate Crisis

The Senate Democrats’ Special Committee on the Climate Crisis has a new report, Climate Action: Building a Clean Economy for the American People. It has a laundry list of the kinds of measures that are needed and that the next Congress could choose to act on. What is really interesting though is the last chapter, which is called Dark Money. It takes solid aim at the fossil fuel industry’s campaign to misinform, disinform, and buy political influence, especially following the Citizens United decision. On the page introducing this topic is a picture of our Supreme Court justices.

The Democratic Senators blame Republicans, of course, but the cirampaigns need to be funded too. They pretty much admit here that big business owns Congress, and the Supreme Court made that happen. Well, remembering my high school civics, the Supreme Court interprets the Constitution, but Congress wrote the Constitution and Congress can change it.

August 2020 in Review

Goodbye summer, hello fall (or do you prefer to say autumn?) in this weird and consequential year.

Most frightening and/or depressing story:

  • We just had the 15-year anniversary of Hurricane Katrina, a major regional crisis that federal, state, and local governments failed to competently prepare for or respond to. People died, and decades later the recovery is incomplete. Coronavirus proves we learned nothing, as it is unfolding in a similar way on a much larger and longer scale. There are many potential crises ahead that we need to prepare for today, not least the inundation of major cities. I had a look at the Democratic and (absence of a) Republican platforms, and there is not enough substance in either when it comes to identifying and preparing for the risks ahead.

Most hopeful story:

  • Automatic stabilizers might be boring but they could have helped the economy in the coronavirus crisis. Congress, you failed us again but you can get this done before the next crisis.

Most interesting story, that was not particularly frightening or hopeful, or perhaps was a mixture of both:

  • Vehicle miles traveled have crashed during the coronavirus crisis. Vehicle-related deaths have decreased, but deaths per mile driven have increased, most likely because people drive faster when there is less traffic, absent safe street designs which we don’t do in the U.S. Vehicle miles will rebound, but an interesting question is whether they will rebound short of where they were. One study predicts about 10% lower. This accounts for all the commuting and shopping trips that won’t be taken, but also the increase in deliveries and truck traffic you might expect as a result. It makes sense – people worry about delivery vehicles, but if each parcel in the vehicle is a car trip to the store not taken, overall traffic should decrease. Even if every 5 parcels are a trip not taken, traffic should decrease. I don’t know the correct number, but you get the idea. Now, how long until people realize it is not worth paying and sacrificing space to have a car sitting there that they seldom use. How long before U.S. planners and engineers adopt best practices on street design that are proven to save lives elsewhere in the world?

humidity helps reduce coronavirus transmission

Humidify those schools!

The relationship between climatic factors and COVID‐19 cases in New South Wales, Australia was investigated during both the exponential and declining phases of the epidemic in 2020, and in different regions. Increased relative humidity was associated with decreased cases in both epidemic phases, and a consistent negative relationship was found between relative humidity and cases. Overall, a decrease in relative humidity of 1% was associated with an increase in cases of 7–8%. Overall, we found no relationship with between [sic] cases and temperature, rainfall or wind speed.

Transboundary and Emerging Diseases

Not being a scientist or doctor, I have always assumed that mucous membranes inside your nose help block germs, and that a dried out nose in the winter time is one reasons colds, coughs, and flu spread through schools and offices every winter. It seems like a relatively simple measure to take that would have a clear positive effect. Now, to sit back and wait for my children’s schools and my office building manager to explain why it can’t be done.

The Republican Party Doesn’t Stand for Anything!

I said I was going to look at the Republican Party Platform.

I have voted for Republican candidates at the state and local level at times in the past. I am sympathetic to pro-business, pro-growth arguments at times. I think that some countries have overreached in terms of taxation and regulation at times. I tried to give the Republican Party the benefit of the doubt. BUT…

Today I confirmed that THERE IS NO REPUBLICAN PARTY PLATFORM. They didn’t meet to discuss one, and didn’t adopt one, in 2020. They are for whatever Trump says, and against whatever Obama and the Democratic Party say. They have no ideas, no policy proposals. They simply don’t stand for anything! This is not propaganda. I am not making this up. This is what their website literally says. Just to make sure I wasn’t missing something, I went to the Republican National Committee website, and clicked on the link to the party platform from there. Here’s what is says:

WHEREAS, The RNC has unanimously voted to forego the Convention Committee on Platform, in appreciation of the fact that it did not want a small contingent of delegates formulating a new platform without the breadth of perspectives within the ever-growing Republican movement…

WHEREAS, The RNC, had the Platform Committee been able to convene in 2020, would have undoubtedly unanimously agreed to reassert the Party’s strong support for President Donald Trump and his Administration

WHEREAS, The RNC enthusiastically supports President Trump and continues to reject the policy positions of the Obama-Biden Administration, as well as those espoused by the Democratic National Committee today; therefore, be it

RESOLVED, That the Republican Party has and will continue to enthusiastically support the President’s America-first agenda;

RESOVLVED [sic], That the 2020 Republican National Convention will adjourn without adopting a new platform until the 2024 Republican National Convention

The Republican Party

Okay, fine, let’s look at the 2016 platform then, and compare it to the policy priorities of my pretend party platform.

  • Anti-corruption? No! They are literally against any limits on the purchasing of influence by the rich and powerful. p. 12.
  • A major childcare, education, and training commitment? No! The health and welfare of children is a paramount responsibility of the government…right up to the point where they are born. From that point, childcare is up to parents alone, preferably two heterosexual parents, and the government will not and should not interfere. Parents should have a choice of schools, which sounds reasonable, but in practice this means defunding the universal public education system. Make sure white people are not discriminated against in college admissions. The government should not provide student loans and higher education should be privatized as much as possible.
  • A major public infrastructure and private capital investment commitment? A major research and development commitment? They talk about technology. They talk about startups. I’ll give them some points for talking about the electric grid, which Democrats don’t mention. They don’t really see an active government role in any of these things, let alone an active funding role. They are maybe open to some funding for R&D in the private health care industry.
  • Universal health care? No! Continue to rely on the failed private market place that provides poor outcomes at the world’s highest prices, for those who are able to obtain care at all.
  • A major risk management program? No, but remember I didn’t give the Democrats a high score on this. I’ll give them some points for talking about food security. I’ll give them some points for talking about cybersecurity. They talk a lot about coal. I wonder if they would still talk about coal so much if they adopted a new platform? They state that the IPCC is a political body, not a scientific one. They reject international agreements on carbon emissions. They want to double down in the war on drugs. They are generally for more military spending, more nuclear weapons, and against arms control agreements. Iran, China, and maybe Russia are the enemies. They are just generally against much involvement in international organizations.
  • New revenue to support investment? No, they’re just generally against taxes.
  • Unemployment, disability, retirement? No, they want to monkey with social security.

I tried to be objective and read the document with fresh eyes. I am generally disgusted by it. This is a party with no ideas for improving the country, and I would not entrust them with leadership of anything. I hope they crash and burn in 2020, and reemerge as a more moderate, pro-business and pro-growth party.

Katrina, 15 years on

August 29, 2020 will be the 20-year anniversary of Hurricane Katrina’s landfall in New Orleans. I think it’s a critical event to understand for at least two reasons. First, it was an early, regional example of U.S. governmental failure to prepare, respond, and recover from a known risk. Now we have a crisis unfolding on a much larger scale, and the government is proving to be just as inept as it was in 2005, with far greater consequences. So I think Katrina was an early warning of government dysfunction that we failed to heed.

As far as coronavirus goes, we are past the prepare stage and it is getting late to mount an effective response. We can still recover though. New Orleans didn’t really recover fully, according to this article.

A year after the storm, over half the city’s schools remained shut; under a third of flooded-out residents had returned; and few buses were running in a city where more than a third of African American households did not own cars. By the second anniversary, no further schools had reopened and damaged rental units largely languished unrepaired. And in 2015, the number of children living in poverty, almost 40 per cent – nearly twice the national average – remained unchanged from when the levees broke.

TLS

So Katrina was a cautionary tale of the U.S. government (and I’m talking federal, state, and local) failing to prepare, respond, and recover from a known risk. On a more literal level, it will not be the last coastal American city to be inundated. Eventually they may all be inundated. It is time to learn from what went wrong in Katrina and figure out how to apply it nationally to prepare, respond, and recover from the disasters that are coming.